Radical-scavenging activity of glutathione, chitin derivatives and their combination‡

Valachová, Katarína; Tamer, Tamer Mahmoud; Eldin, M.S. Mohy; Šoltés, Ladislav

doi:10.1515/chempap-2016-0011

Cited by 17 publications

(13 citation statements)

References 17 publications

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“…The presence of deacetyl amine groups along polymer backbone provided its basic character and simplified its solubility in the acidic medium. The unique properties of chitosan such as non-toxicity, anti-bacterial activity, biodegradability and excellent biocompatibility 9 , 10 renders it widely used in the bio-medical applications as a drug carrier 11 , antimicrobial 12 , antioxidant 13 , antitumor 14 , and a wound dressing agent 15 , 16 . Therefore, chemical modifications of chitosan simplify its chemical transformation through the present NH 2 and OH − groups and allow the formation of several functional derivatives such as sulfonation 17 , amination 18 and carboxymethylation 19 .…”

Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Hassan

Omer

Abbas

et al. 2018

Sci Rep

175

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This study intends to develop novel two antimicrobial phenolic chitosan Schiff bases (I) and (II) via coupling of chitosan with Indole-3-carboxaldehyde and 4-dimethylaminobenzaldehyde, respectively, for boosting the antimicrobial activity of native chitosan. The alterations in the chemical structure and morphology of the Schiff bases were verified using FT-IR, electronic spectrum analysis, and SEM, whereas the thermal properties were investigated by TGA and DSC instruments. The results obtained from the potentiometric analysis referred that the degrees of substitution were 1.15 and 12.05% for Schiff bases (I) and (II), respectively. The antimicrobial activities of Schiff base (I) were significantly augmented more than Schiff base (II) and chitosan. Minimum inhibitory concentration (MIC) of Schiff base (I) was perceived at 50 µg/ml against tested microorganisms except for B. cereus and C. albicans. The highest concentration of Schiff base (I) could inhibit the growth of Gram-positive up to 99%. However, Schiff base (II) recorded the maximum inhibition rate versus Gram-positive approximately 82%. The cytotoxicity of the developed materials was estimated by MTT assay that substantiated their safety to fibroblast cells. The findings emphasized that the developed Schiff bases might be implemented as antimicrobial contenders to pure chitosan for treatments of wound infections.

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Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Hassan

Omer

Abbas

et al. 2018

Sci Rep

175

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“…(Other methods used were infrared spectroscopy [34,35], thermal chemiluminescence [34,35,63] and EPR spectroscopy [35,64], the last one to identify the formation of radicals in selected oxidation systems.) To comment the below represented experimental results it should be claimed that, as repeatedly proved [15][16][17][18]45,51,65,66], the decrease in dynamic viscosity values reflects the decrease in average molar mass of the HA sample with respect to the existing functional dependence η = f (M).…”

Section: Assessment the Substance Antioxidative Profile By Hyaluronan Plus The Weissberger Systemmentioning

confidence: 88%

“…However, as often claimed, the so called Weissberger system-ascorbate---Cu(II/Cu(I)---dioxygen [7][8][9]-generates hydrogen peroxide molecules (cf. Scheme 1) [10][11][12][13], or due to the decomposition of H2O2 by Cu(I) complex through Fenton type reaction, the Weissberger system became one of the most potent generators of hydroxyl radicals [14][15][16].…”

Section: Sequestration Of Copper Cations With Ascorbatementioning

confidence: 99%

“…As shown in the sub-section "Sequestration of copper cations with ascorbate" for the generation of • OH radical(s) the so called Weissberger biogenic oxidative system can produce a continual flux of hydroxyl radicals [15,16]. (To simplify some reaction sequences appearing in this minireview, HA abbreviates the hyaluronan macromolecule.…”

Section: Initiation Reaction(s)mentioning

confidence: 99%

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Assessment of the Substance Antioxidative Profile by Hyaluronan, Cu(II) and Ascorbate

Valachová

Šoltés

2021

Pharmaceutics

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In the minireview presented here, the authors discuss the evaluation of inhibitory effect of substances in the phases of initiation and propagation of high-molar-mass hyaluronan oxidative degradation. The experimental approach should be considered as original since on using a simple experimental assay it is possible to prove both the so-called “preventive” and “chain-breaking” antioxidant activity of investigated water-soluble endo- or exogenous substances.

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“…By simple deacetylation process, chitosan can be easily extracted from chitin via deacetylated unit (β-(1-4)-linked d-glucosamine) copolymer as characterized by its basic character and simplified its solubility in the acitic acid, non-toxic, anti-bacterial activity, biodegradability and excellent biocompatibility [8][9][10]. So, it widely used in the bio-medical applications as a drug carrier [11], antimicrobial [12], antioxidant [13], antitumor [14], and a wound dressing agent [15,16].…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis of spiro quinazolinone compacted with chitosan through DFT approach for interference the antimicrobial activity

Nasser¹,

Hafez²,

Badawy³

et al. 2019

Open J. Chem.

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In this work, we present a newly three antimicrobial chitosan, 2-benzoxazinyl benzoic acid (BBA) and novel biopolymer of Chitosan-spiroquinazolinone (SQC) via coupling of chitosan with benzoxazinyl benzoic acid, for promoting the antimicrobial activity of inherent chitosan. Modification in the chemical structure of the synthesized product SQC was confirmed using FT-IR and UV analysis. The antimicrobial activities of Chitosan, and BBA compounds were expressively increased more than chitosan-spiroquinazolinone SQC. Minimum inhibitory concentration (MIC) of compound SQC was supposed at 50µg/ml against tested microorganisms except for B.cereus and C.albicans. The highest concentration of Chitosan would prevent the growth of Gram-+ve upto 99%. However, compound BBA recorded the maximum inhibition percentage versus Gram-+ve approximately 82%. The findings emphasized that the developed Chitosan-Spiroquinazolinone SQC may be blocker for antimicrobial activity to pure chitosan and BBA i.e, stop reaction if possible for actions of antimicrobial treatments.

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Radical-scavenging activity of glutathione, chitin derivatives and their combination‡

Cited by 17 publications

References 17 publications

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Assessment of the Substance Antioxidative Profile by Hyaluronan, Cu(II) and Ascorbate

Design, synthesis of spiro quinazolinone compacted with chitosan through DFT approach for interference the antimicrobial activity

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