Radical resection and enucleation in Chinese adolescents with pancreatic tumors

Abstract

Pancreatic tumors rarely occur in adolescents, and the appropriateness of radical resection for these patients remains controversial.Medical records were retrospectively reviewed for patients younger than 19 years who underwent radical resection or limited resection (enucleation) between 2000 and 2015. Patient demographics, clinical characteristics, operative details, growth, and survival were analyzed.During the study period, 11 adolescents (mean age, 16.18 years; standard deviation, 1.99; interquartile range, 15.0–18.0) underwent radical resection (n = 7) or enucleation (n = 4) to treat solid pseudopapillary tumors (n = 5), pancreatic neuroendocrine tumors (n = 5), or pancreatic ductal adenocarcinoma (n = 1). None of the 7 patients who underwent radical resection experienced recurrence or serious complications, while 3 of 4 patients who underwent enucleation experienced recurrence (P = 0.02). Recurrence-free survival was slightly longer in patients who underwent radical resection, and this procedure did not appear to affect adolescent growth and development.Radical resection might be safe and effective for adolescents with pancreatic tumors.

Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms: A retrospective study with a large sample size

“…PPM is increasingly used for low-grade or benign pancreatic neoplasms[ 23 , 24 ]. However, research regarding PPM of SPN is limited and mainly based on case reports and retrospective studies with small sample sizes[ 25 - 27 ] due to the rarity of the disease. However, the results were inconsistent.…”

“…In their study, 31 patients who underwent enucleation were included. Yao et al [ 27 ] concluded that CP was associated with a lower RFS rate than enucleation. However, only 11 patients were included in this case series, and only 5 of them were diagnosed with SPNs.…”