Radical Prostatectomy and Robotic Radiosurgery as Treatment Options for Localized Prostate Cancer

Киприянов, Е. А.; Карнаух, П. А.; Важенин, И А; Важенин, А. В.

doi:10.21294/1814-4861-2020-19-1-50-56

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…It radiates higher prostate radiation doses, with less emission to the surrounding tissues. Radiation therapy is considered to be an effective intermediate-risk and high-risk prostate cancer treatment when used together with androgen deprivation therapy (ADT) [ 80 ]. It is a suitable therapy for attenuating metastasizing cancer cells.…”

Section: Methodsmentioning

confidence: 99%

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Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

et al. 2022

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Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally. Patients affected with prostate cancer present with either a localized or advanced disease. In this review, we aim to provide a holistic overview of prostate cancer, including the diagnosis of the disease, mutations leading to the onset and progression of the disease, and treatment options. Prostate cancer diagnoses include a digital rectal examination, prostate-specific antigen analysis, and prostate biopsies. Mutations in certain genes are linked to the onset, progression, and metastasis of the cancer. Treatment for localized prostate cancer encompasses active surveillance, ablative radiotherapy, and radical prostatectomy. Men who relapse or present metastatic prostate cancer receive androgen deprivation therapy (ADT), salvage radiotherapy, and chemotherapy. Currently, available treatment options are more effective when used as combination therapy; however, despite available treatment options, prostate cancer remains to be incurable. There has been ongoing research on finding and identifying other treatment approaches such as the use of traditional medicine, the application of nanotechnologies, and gene therapy to combat prostate cancer, drug resistance, as well as to reduce the adverse effects that come with current treatment options. In this article, we summarize the genes involved in prostate cancer, available treatment options, and current research on alternative treatment options.

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Section: Methodsmentioning

confidence: 99%

“…Gene expression profiling results have indicated an overexpression in EZH2 mRNA and proteins present in metastatic prostate cancer. Due to the functions of EZH2 involving apoptosis and proliferation, EZH2 is a novel target for prostate cancer [ 80 ].…”

Section: Figurementioning

confidence: 99%

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

et al. 2022

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“…It can be used as an alternative to surgery or after surgery to prevent cancer recurrence. External beam radiation therapy delivers precise radiation to prostate tissue, sparing healthy cells, and is considered effective for intermediate-risk and high-risk PCa [53]. However, studies have shown that PCa cells can adapt to radiotherapy, increasing the risk of disease recurrence [54].…”

Section: Current Therapeutic Strategies Used In Prostate Cancermentioning

confidence: 99%

Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

Fernandes,

Costa,

Fernandes

et al. 2023

Biomedicines

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Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis. However, the mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects the diagnosis methods for PCa and the pathophysiological mechanisms underlying the disease, clarifying the dynamic interplay between inflammation and leukocytes in promoting tumour development and spread. It provides updates on recent advances in elucidating and treating prostate carcinogenesis, and opens new insights for the use of bioactive compounds in PCa. Polyphenols, with their noteworthy antioxidant and anti-inflammatory properties, along with their synergistic potential when combined with conventional treatments, offer promising prospects for innovative therapeutic strategies. Evidence from the use of polyphenols and polyphenol-based nanoparticles in PCa revealed their positive effects in controlling tumour growth, proliferation, and metastasis. By consolidating the diverse features of PCa research, this review aims to contribute to increased understanding of the disease and stimulate further research into the role of polyphenols and polyphenol-based nanoparticles in its management.

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Radical Prostatectomy and Robotic Radiosurgery as Treatment Options for Localized Prostate Cancer

Cited by 2 publications

References 3 publications

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

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