“…It has been reported by many clinicians that honey promotes the formation of clean healthy granulation tissue (the clusters of fibroblasts around new capillary beds that is the regenerating connective tissue) 17,25,31,46,49,50,55,74,132,143 . It has also been reported that honey hastens epithelialization of the wound (coverage with a new outer layer of skin) 49,50,70,130,132 , making skin grafting unnecessary 31,50,70,91,132 . This growth-stimulating property of honey has been confirmed histologically in many studies of wounds in animals 20,30,63,85,113 , as has a stimulation of the synthesis of collagen fibres 134 and other connective tissue components 133 , and improvement of the strength of collagen 134 .…”