Radical Operation for Carcinoma of the Vulva

Cavanagh, Denis; Beazley, J. M.; Ostapowicz, F

doi:10.1111/j.1471-0528.1970.tb03455.x

Cited by 87 publications

(29 citation statements)

References 1 publication

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“…Because people generally are unaware of the historical usage of honey as a wound dressing, or know only of its ancient usage, its clinical usage is presumed to be a new development or something that has been "rediscovered". 9 However, a look at the reference list at the end of this paper will reveal reports of clinical usage published in the 1950s, 10,11 1960s, 12 1970s, [13][14][15][16] and 1980s [17][18][19][20][21][22][23] as well as the rapidly increasing number since it apparent "rediscovery". Clinicians need to decide if modern wound-care products are likely to give better results than this long-established wound dressing material.…”

Section: Discussionmentioning

confidence: 99%

The Evidence Supporting the Use of Honey as a Wound Dressing

Molan

2006

The International Journal of Lower Extremity Wounds

388

302

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Some clinicians are under the impression that there is little or no evidence to support the use of honey as a wound dressing. This impression is reinforced by it being concluded in systematic reviews that the evidence is not of a high standard. But likewise the evidence for modern wound dressing products is of not of a high standard. For evidence-based medicine to be practised in wound care, when deciding which product to use to dress a wound it is necessary to compare the evidence that does exist, rather than be influenced by advertising and other forms of sales promotion. To allow sound decisions to be made, this review has covered the various reports that have been Key words: evidence, honey, infected wounds, surgical wounds, burns, ulcers, abscesses, skin grafts, moist dressings, non-stick, debriding, deodorising, antibacterial, anti-inflammatory, prevention of scarring 3 There is a rapidly increasing interest in the use of honey as a wound dressing, but it is common to hear clinicians express the opinion that there is no evidence to support the use of honey as a wound dressing. However, the impression upon which this opinion is based is most likely to be a reflection of the scarcity of advertising and other commercial promotion of honey for wound care relative to that of other wound care products. Even where reviews of clinical evidence for the use of honey have been published, a negative impression is often obtained from consulting these, as the conclusions stated are that the evidence is of low quality and/or that there is a need for more evidence.1-6 But the myriad of advertisements for modern wound dressings possibly blinds people to the fact that only small, poor-quality trials exist to support the use of these products. The literature cited was found by searching the PubMed, BIOSIS and ISI Web of Science databases for the term "honey". Also, literature not included in the databases was found from citations in papers that were. Excluded were papers where honey was used in a mixture with other therapeutic substances, papers giving brief reports on the use of honey on cases where there was insufficient information on the cases given for the reader to judge if the positive outcomes were the result of honey being more effective than the prior treatment, and papers that were expressions of opinion rather than reports of treatment of wounds with honey. Conference presentations were also excluded. CLINICAL EVIDENCE 4Many randomised controlled trials have been carried out comparing honey with various other wound treatments. These trials and the results obtained from them are summarised in Table 1. Other clinical trials have been conducted where the form of the trial has been other than a randomised controlled trial. In some of these the results for

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Section: Discussionmentioning

confidence: 99%

The Evidence Supporting the Use of Honey as a Wound Dressing

Molan

2006

The International Journal of Lower Extremity Wounds

388

302

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“…Cavanagh, Beazley and Ostapowicz (1970) found that a 100% (v/v) concentration of honey had a complete fungicidal effect on C. albicans, while a 50% concentration was necessary to bring about the same action in the species of C. stellatoidea, C. reukaufii and C. tropicalis. However, only a 10% (v/v) honey concentration was necessary for a fungicidal effect against C. pseudotropicalis.…”

Section: Discussionmentioning

confidence: 97%

The antifungal action of three South African honeys on Candida albicans

2001

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-The purpose of this study was to investigate the antifungal action of three single samples of South African honey (wasbessie, bluegum and fynbos) against Candida albicans. Various dilutions of honey were prepared in brain-heart infusion broth, ranging in concentration from 0 to 25% (w/w). This was inoculated with C. albicans, while a hypertonic sugar solution served as a control. All dilutions were incubated overnight and the optical density was measured in a spectrophotometer. The sugar control and the 3 honey samples stimulated the growth of C. albicans and was optimal between 2.5% and 5%. Increased honey concentrations resulted in reduced growth of C. albicans; wasbessie honey at a concentration of 25% demonstrated 29.4% inhibition on the growth of C. albicans, while the control, bluegum and fynbos honey produced only partial inhibition.honey / antifungal action / antimicrobial action / oral micro flora / Candida albicans

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“…The fairly extensive usage of honey in medical practice in major lesions has shown no indication of tissue damage: to the contrary, it actually appears to promote tissue repair (Cavanagh et al 1970;Armon 1980;Bergman et al 1983;Effem 1988). Thus it would be warranted to conduct a clinical trial of intramammary honey therapy for mastitis in dairy cows or goats.…”

Section: Assay Of Antibacterial Activitymentioning

confidence: 99%

“…Its use has been re-discovered by the medical profession in more recent times, and there are many reports of its effectiveness as an antibacterial agent for the treatment of ulcers, bed sores, and other surface infections resulting from burns and wounds (Zumla & Lulat 1989). In many of the cases reported, honey was used on infections not responding to standard antibiotic and antiseptic therapy, and it was found in almost all of the cases to be very effective in rapidly clearing up infection and promoting healing (Hutton 1966;Cavanagh et al 1970;Blomfield 1973;Armon,1980;Braniki 1981;Effem 1988;Farouk et al 1988). It is generally reported to be painless and has been used to treat deep abscesses and eye infections (Bulman 1955;Osaulko 1953).…”

Section: Introductionmentioning

confidence: 99%

The sensitivity of mastitis‐causing bacteria to the antibacterial activity of honey

Allen

Molan

1997

New Zealand Journal of Agricultural Research

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The use of honey as a wound dressing is well established in traditional and modern medicine. There are many reports of its effectiveness in clearing bacterial infections in ulcers and abscesses, which suggest that it may be suitable for the intramammary treatment of mastitis. To evaluate this possibility, the species of bacteria that commonly cause mastitis in dairy cows were tested for their sensitivity to the antibacterial activity of honey. The growth of all seven species tested was completely inhibited by a typical honey (with antibacterial activity attributed to its content of hydrogen peroxide) at a concentration of 10% (v/ v) in the agar plates, and two by 5% honey. Six of the species were completely inhibited by a typical manuka honey (with antibacterial activity attributed to its content of a non-peroxide component) at a concentration of 5% (v/v). Only one species was inhibited by 10% (v/v) artificial honey (sugars and gluconic acid as in honey). As honey is harmless to tissues and would leave no undesirable residues in milk, it would be of interest to now evaluate it therapeutically in clinical mastitis.

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Radical Operation for Carcinoma of the Vulva

Cited by 87 publications

References 1 publication

The Evidence Supporting the Use of Honey as a Wound Dressing

The Evidence Supporting the Use of Honey as a Wound Dressing

The antifungal action of three South African honeys on Candida albicans

The sensitivity of mastitis‐causing bacteria to the antibacterial activity of honey

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