“…20 Also, cells are commonly immobilized in hydrogel matrices for various purposes. Such gels are sensitive to small changes in the environment and give the response to physical stimuli (temperature, 25 light, 26 pressure, 27 electric fields, 28 ionic strength, 29 and magnetic field 30 ), chemical stimuli (pH, 31 ions 32 ), or biological stimuli (glucose, 33 enzyme, 34 and antigen 35 ) through volume changes. As a result of recognition, volumetric change creates a new kind of sensing system instead of the classical biosensor based on the electrochemical way.…”