Radical hysterectomy for FIGO stage I–IIB adenocarcinoma of the uterine cervix

Kasamatsu, T.; Onda, Takashi; Sawada, Morio; Kato, Tomoyasu; Ikeda, Shun‐ichi; Sasajima, Yuko; Tsuda, Hitoshi

doi:10.1038/sj.bjc.6605048

Cited by 74 publications

(82 citation statements)

References 20 publications

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“…Consistently reported independent adverse prognostic factors for patients with early-stage cervical cancer after RH include higher FIGO stage, lymph node metastasis, parametrial involvement, depth of cervical stromal invasion, tumour size and LVSI (Look et al, 1996;Lai et al, 2007;Kasamatsu et al, 2009). We also found that these factors were significant in univariate analysis, although only lymph node metastasis, parametrial involvement and tumour size were significant in multivariate analysis.…”

Section: Discussionmentioning

confidence: 50%

“…Although several studies reported that the time to recurrence was shorter in patients with AdCa and AdSCCa than in those with SCCa, more recent work has found no difference associated with histologic type (Look et al, 1996;Lai et al, 1999). When classified into recurrence inside and outside the pelvis, the pattern of spread and recurrence did not differ among histologic groups in some studies (Look et al, 1996;Lai et al, 1999;Grisaru et al, 2001), whereas other reports showed an association between histologic type and more frequent disseminated peritoneal spread or distant metastasis (Drescher et al, 1989;Eifel et al, 1995;Kasamatsu et al, 2009). In our series, recurrence outside the pelvis was more frequent in patients with AdCa.…”

Section: Discussionmentioning

confidence: 71%

“…The prognosis of patients with AdCa after RH is unclear, primarily because studies have been performed on small numbers of patients. Some of these studies found that patients with AdCa have poorer prognosis than do those with SCCa (Hopkins and Morley, 1991;Eifel et al, 1995;Look et al, 1996;Samlal et al, 1997;Lai et al, 1999;Kim et al, 2000;Nakanishi et al, 2000), whereas other reports found no differences in prognosis (AntonCulver et al, 1992;Miller et al, 1993;Shingleton et al, 1995;Grisaru et al, 2001;Ayhan et al, 2004;Lee et al, 2006;Fregnani et al, 2008;Kasamatsu et al, 2009). Therefore, the prognosis after RH and the optimal management of AdCa are still a subject of debate.…”

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confidence: 87%

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Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Kim

et al. 2010

Br J Cancer

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BACKGROUND: To determine the prognostic factors and treatment outcomes of patients with early-stage adenocarcinoma (AdCa) of uterine cervix who underwent radical hysterectomy (RH). METHODS: Patients with early-stage squamous cell carcinoma (SCCa) of the uterine cervix who underwent RH were compared with patients with AdCa by multivariate analysis. RESULTS: A total of 1218 patients were eligible, of which 996 (81.8%) had SCCa and 222 (18.2%) had AdCa. In multivariate analysis, parametrial involvement and lymph node metastasis were significant factors for both recurrence-free survival(RFS) and overall survival (OS) of patients with AdCa, whereas age, tumour size, parametrial involvement and lymph node metastasis were significant factors for both RFS and OS of patients with SCCa. After adjusting for significant prognostic factors, patients with AdCa had significantly poorer RFS (odds ratio (OR) ¼ 2.07, 95% confidence interval (CI) ¼ 1.37 -3.12, P ¼ 0.001) and OS (OR ¼ 2.56, 95% CI ¼ 1.65 -3.96, Po0.001) than patients with SCCa. Recurrence outside the pelvis was more frequent in AdCa than in those with SCCa (75 vs 57.8%, P ¼ 0.084). CONCLUSION(S): Although RH is still acceptable for treatment of patients with AdCa, a more effective systemic adjuvant therapy is required.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 71%

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confidence: 87%

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Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Kim

et al. 2010

Br J Cancer

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“…The Gynecologic Oncology Group study demonstrated that there was no difference in the distribution of high-risk pathological factors (pelvic node metastasis, parametrial extension, and surgical margins) and survival between cell types, but there was shorter survival in those with adenosquamous carcinoma (Look et al, 1996). Similarly, Kasamatsu et al reported that for FIGO stage I-IIB cervical cancer patients who had radical hysterectomy, the spread pattern and prognosis were comparable between those with squamous cell carcinoma and adenocarcinoma (Kasamatsu et al, 2009). Data from the previous study by our group were in accordance with these findings (Rudtanasudjatum et al, 2011).…”

Section: Discussionmentioning

confidence: 97%

Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

Sethasathien

Charoenkwan²,

Settakorn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008). Some studies have reported 2.6-2.9 times higher mortality among patients with early stage ADC compared with early-stage SCC patients over 10-19 years of follow-up (Nakanishi et al, 2000;Takeda et al, 2002;Park et al, 2010;Mabuchi et al, 2012) while others have not found any significant difference in survival among patients with SCC and ADC (Shingleton et al, 1995;Lee et al, 2006;Fregnani et al, 2008;Kasamatsu et al, 2009;Narukon et al, 2010). Moreover, only few studies have included patients with SNEC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Intaraphet

Kasatpibal²,

Siriaunkgul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the third most common cancer among women worldwide, accounting for approximately 13% of all cancers in women, with 529,800 new cases and 275,100 deaths in 2008. More than 85% of the cases and about 88% of all deaths occurred in developing countries (Ferlay, 2010;Jemal et al., 2011). At the same time, the incidence of cervical cancer has decreased dramatically in developed countries with well-developed screening programs concomitant with substantial survival AbstractBackground: Clarifying the prognostic impact of histological type is an essential issue that may influence the treatment and follow-up planning of newly diagnosed cervical cancer cases. This study aimed to evaluate the prognostic impact of histological type on survival and mortality in patients with cervical squamous cell carcinoma (SCC), adenocarcinoma (ADC) and small cell neuroendocrine carcinoma (SNEC). Materials and Methods: All patients with cervical cancer diagnosed and treated at Chiang Mai University Hospital between January 1995 and October 2011 were eligible. We included all patients with SNEC and a random weighted sample of patients with SCC and ADC. We used competing-risks regression analysis to evaluate the association between histological type and cancer-specific survival and mortality. Results: Of all 2,108 patients, 1,632 (77.4%) had SCC, 346 (16.4%) had ADC and 130 (6.2%) had SNEC. Overall, five-year cancer-specific survival was 60.0%, 54.7%, and 48.4% in patients with SCC, ADC and SNEC, respectively. After adjusting for other clinical and pathological factors, patients with SNEC and ADC had higher risk of cancer-related death compared with SCC patients (hazard ratio [HR] 2.6; 95% CI, 1.9-3.5 and HR 1.3; 95% CI, 1.1-1.5, respectively). Patients with SNEC were younger and had higher risk of cancer-related death in both early and advanced stages compared with SCC patients (HR 4.9; 95% CI, 2.7-9.1 and HR 2.5; 95% CI, 1.7-3.5, respectively). Those with advanced-stage ADC had a greater risk of cancer-related death (HR 1.4; 95% CI, 1.2-1.7) compared with those with advanced-stage SCC, while no significant difference was observed in patients with early stage lesions. Conclusion: Histological type is an important prognostic factor among patients with cervical cancer in Thailand. Though patients with SNEC were younger and more often had a diagnosis of early stage compared with ADC and SCC, SNEC was associated with poorest survival. ADC was associated with poorer survival compared with SCC in advanced stages, while no difference was observed at early stages. Further tailored treatment-strategies and follow-up planning among patients with different histological types should be considered.

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Radical hysterectomy for FIGO stage I–IIB adenocarcinoma of the uterine cervix

Cited by 74 publications

References 20 publications

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

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