Radical cystectomy in octogenarians

Abstract

This retrospective study evaluates the morbidity and outcome of cystectomy and urinary diversion in octogenarians with invasive bladder cancer. Records of all patients older than 80 years who underwent cystectomy during the last 10 years were analyzed retrospectively. Among 565 cystectomies, 11(< 2%) patients were identified and evaluated for intraoperative and postoperative complications and mortality post surgery. The median age was 82 years. One female and ten male patients were selected. Eight patients were hypertensive, three were diabetic, one had coronary artery disease, two had chronic lung disease and one had depression. Seven patients presented with hematuria, two had lower urinary tract symptoms and two presented with renal failure who were optimized for renal function. All patients had ileal conduit as the form of urinary diversion. Simultaneous urethrectomy was done in two patients. Median surgical time was 5 h. Median hospital stay after surgery was 10 days. Four patients had pneumonitis and one patient developed hemiplegia, but all patients were eventually discharged. One patient expired due to stent septicemia within one month after discharge. Follow-up ranged from four months to five years. Three patients expired three years after surgery—one due to disease recurrence and the other two due to unrelated cause. One patient was lost to follow-up and six patients are doing well. Our results support the use of cystectomy in octogenarians with invasive bladder cancer, which has acceptable morbidity and mortality, and offers the best chance for sustained disease-free quality survival.

Bricker ileal conduit vs. Cutaneous ureterostomy after radical cystectomy for bladder cancer: a systematic review

“…In a more recent SEER analysis, 18.9% of patients with MIBC underwent RC (29). For patients with more than 80 years old, only 6.9% underwent RC (30). Older age, Charlson Comorbidity Index >2, and ethnicity (non-Hispanic black patients) were factors related to decreased odds of receiving RC (28,29).…”

“…Chronological age, per se, is not a contraindication for RC. There is a good body of literature to support that RC can be performed safely in the elderly (30)(31)(32). On the other hand, several studies advocate that increasing age is associated with both mortality and complications after RC (33)(34)(35).…”

Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

“…Wound healing includes different processes such as epithelialization formation, contraction, and fibrosis. The healing process is largely dependent on the biosynthesis, accumulation, and subsequent maturation of new collagens [57] . Granulation tissue contains collagen fibers, fibroblasts, fibrocyte, edema, and newly formed blood vessels [58] .…”

“…The healing process is largely dependent on the biosynthesis, accumulation, and subsequent maturation of new collagens. [57] Granulation tissue contains collagen fibers, fibroblasts, fibrocyte, edema, and newly formed blood vessels. [58] In the histopathological evaluation, granulation tissue formation with prominent fibrocyte, collagen and angiogenesis were detected in groups treated with 0.5 g/day (group-3) and 1 g/day (group-4) A. sintenisii extract (Figure 3).…”