Radical copolymerization of sodium 2-acrylamido-2-methylpropane sulfonate and sodium acrylate in water-alcohol solutions

Abstract

Water soluble copolymers of 2 acrylamido 2 meth ylpropane sulfonic acid and acrylic acid are used as flocculants [1, 2] and stabilizers of disperse systems [1], as inhibitors of the deposition of aluminum and iron salts in aqueous systems [3, 4], as thickeners [5], and as antistatic agents [6]. The efficiency of applica tion of copolymers is determined by their molecular mass characteristics that, in the copolymerization of ionogenic monomers, are usually controlled with the use of solvents of different natures [7, 8]. Varying the nature and composition of a binary solvent makes it possible to change parameters of the reaction solution and to govern the copolymerization process. In [11], the effect of the ionic strength of solutions (due to NaCl additives [9] and a change in the concentration of the monomer mixture [10]) on the copolymeriza tion of the sodium salt of 2 acrylamido 2 methylpro pane sulfonic acid (Na AMS) and the sodium salt of acrylic acid (Na AA) in aqueous solutions was studied and the influence of the nature of a cation (Na + , ) on the copolymerization of Na AMS and acrylic acid † Deceased. N 4 + salts in aqueous solutions was estimated. This current study concerns the homogeneous copolymerization of these monomers in water-alcohol (methanol or iso propanol) mixtures differing in solvation and ioniza tion capacity. EXPERIMENTAL Na AMS was obtained via the potentiometric titration of an aqueous solution of 2 acrylamido 2 methylpropane sulfonic acid (Lubrizol, United King dom, Т m = 185°С) with a NaOH aqueous solution to pH 9. Na AA was prepared via a biocatalytic method (OAO Bioamid, Saratov) and used as a 31% aqueous solution. Potassium persulfate was recrystallized twice from aqueous solutions. (Its content, as determined via the redox method, was 97.8%.) Other reagents of the reagent grade were used as received; helium was of the high purity grade. All solutions were prepared in distilled water.Copolymerization was performed as described in [9]. Before experiments, the monomer solutions were bubbled with helium. Copolymerization reactions Abstract-The effect of the nature of a solvent on the kinetic parameters of the process and the intrinsic vis cosities of copolymers formed by the homogeneous free radical copolymerization of the sodium salt of 2 acrylamido 2 methylpropane sulfonic acid and the sodium salt of acrylic acid initiated by potassium per sulfate in water, water-methanol mixtures (92 : 8, 84 : 16, 75 : 25, 50 : 50), and water-isopropanol (50 : 50) mixtures at pH 9 and 60°C is studied. The initial rate of copolymerization increases with increases in the con centrations of the comonomers and initiator, the content of 2 acrylamido 2 methylpropane sulfonic acid in the initial monomer mixture, and the content of water in a water-methanol mixture and in the sequence of solvents water-methanol < water-isopropanol. The intrinsic viscosity and yield of the copolymer grow when the content of 2 acrylamido 2 methylpropane sulfonic acid in the initial monomer mixture and water in water-methano...

Antimitogenic Polymer Drugs Based on AMPS: Monomer Distribution−Bioactivity Relationship of Water-Soluble Macromolecules

“…Reactivity ratios of poly(VP- co -AMPS) system have been previously determined by Kurenkov et al – However, these kinetic parameters are strongly affected by the nature of the reaction medium. Our copolymers were obtained in water/dioxane (80:20), whereas Kurenkov’s were synthesized in water, water−ethanol solutions, or DMSO.…”

“…This modulated the hydrophobic/hydrophilic balance of the copolymers and therefore their solubility and stability in the physiological medium. Reactivity ratios of poly(VP-co-AMPS) system have been previously determined by Kurenkov et al [21][22][23][24] However, these kinetic parameters are strongly affected by the nature of the reaction medium. Our copolymers were obtained in water/ dioxane (80:20), whereas Kurenkov's were synthesized in water, water-ethanol solutions, or DMSO.…”