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The aim of this article is to provide a concise review mainly on the practical synthetic applications and to a lesser extent on the fundamentals of fullerenes' radical chemistry. From a practical point of view, we demonstrate that the employment of radical reactions in fullerene chemistry has led to the synthesis of a variety of structurally diverse fullerene derivatives which would be otherwise inaccessible. In this context, the major types of neutral or ion radical additions to C 60 are reported. Such reactions include the addition of radicals of different chemical nature, including C‐, Si‐, O‐, S‐, P‐, and metal‐centered radicals, to C 60 or C 70 . From a fundamental perspective, we report on some of the basic characteristics of the radical reactions of fullerenes, such as the tendency of free radicals to add, multiply, and fast to C 60 and the tendency of the resulting RC 60 · to dimerize.
The aim of this article is to provide a concise review mainly on the practical synthetic applications and to a lesser extent on the fundamentals of fullerenes' radical chemistry. From a practical point of view, we demonstrate that the employment of radical reactions in fullerene chemistry has led to the synthesis of a variety of structurally diverse fullerene derivatives which would be otherwise inaccessible. In this context, the major types of neutral or ion radical additions to C 60 are reported. Such reactions include the addition of radicals of different chemical nature, including C‐, Si‐, O‐, S‐, P‐, and metal‐centered radicals, to C 60 or C 70 . From a fundamental perspective, we report on some of the basic characteristics of the radical reactions of fullerenes, such as the tendency of free radicals to add, multiply, and fast to C 60 and the tendency of the resulting RC 60 · to dimerize.
It is known that an excess amount of (oxygen) radicals in the skin can lead to (local cellular) oxidative stress. From one side, oxidative stress can contribute to the existence of various (inflammatory) skin diseases such as acne vulgaris and alopecia, as well as to accelerated photo-ageing of the skin. From the other side, oxidative stress could also be a wanted process for curing particular skin diseases, such as skin cancer and microbial skin infections. Therefore, novel treatment agents with the ability to scavenge or generate radicals can potentially be meaningful in the treatment of various skin diseases, especially for those diseases that have limited effective treatment options. This viewpoint essay will discuss the potential of fullerene C 60 , i.e. buckminsterfullerene, derivatives as novel treatment agents in dermatology. Fullerene C 60 is an all carbon molecule with a unique dual ability; fullerene C 60 can act as a radical scavenger or as an oxygen radical generator. Hence, fullerene C 60 derivatives offers most interesting prospects as a therapeutic protective or therapeutic toxic agent. Because of their extraordinary physicochemical properties and numerous chemical functionalization possibilities, chemists can design derivatives with a wide scope of unique properties. The experimental data, mostly from in vitro and in vivo animal studies, on the safety and therapeutic potential of fullerene C 60 derivatives, in the field of dermatology will be discussed. K E Y W O R D Santicancer, antimicrobial, antioxidant, dermatology, fullerene C 60 , inflammatory skin diseases, photodynamic therapy, reactive oxygen species, topical drug, UVR protection
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