Radical abdominal trachelectomy in the 19th gestation week in patients with early invasive cervical carcinoma: case study and overview of literature

Mandić, Aljoša; Novakovic, Petar; Nincic, Dejan; Zivaljevic, Milica; Rajovic, Jelka

doi:10.1016/j.ajog.2009.05.002

Cited by 37 publications

(27 citation statements)

References 24 publications

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“…Among the pregnancies that occurred, 18% ended in a miscarriage, and 38% resulted in preterm delivery (< 37 weeks). Another study noted a 20% risk of preterm labor, with approximately 21% of pregnancies ending in miscarriage in the first trimester and 8% ending in miscarriage in the second trimester [10]. …”

Section: Introductionmentioning

confidence: 99%

Conservative surgery in early-stage cervical cancer: What percentage of patients may be eligible for conization and lymphadenectomy?

Smith

Frumovitz

Schmeler

et al. 2010

Gynecologic Oncology

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Objective To determine the proportion of young patients with early-stage invasive cervical cancer treated with radical hysterectomy who may have been eligible for fertility-sparing surgery consisting of cervical conization with pelvic lymph node dissection. Methods We retrospectively identified all patients with early-stage cervical cancer (stage IA2-IB1) who underwent a radical hysterectomy at The University of Texas M. D. Anderson Cancer Center between 1990 and 2009. We reviewed these patients’ records to identify patients who were < 40 years who had not previously undergone tubal ligation and who would have been considered candidates for cold-knife conization with pelvic lymph node dissection—i.e., women with tumors smaller than 2 cm, low-risk histology (squamous, adenocarcinoma, or adenosquamous), and no lymphovascular space invasion (LVSI). Results A total of 507 patients with early-stage cervical cancer were identified who underwent radical hysterectomy during the review period. Of these women, 277 (55%) were 40 years or younger. Of these 277 patients, 75 (27%) had had a previous tubal ligation and 202 (73%) had not. Of these 202 patients potentially interested in fertility preserving surgery, 53 (26%) had favorable pathologic characteristics including low-risk histology, tumors ≤2cms in size and no LVSI present. Of these 53 patients, none had parametrial involvement or positive lymph nodes. Conclusion Among 202 women with age younger than 40 years and no previous tubal ligation who underwent radical hysterectomy, 53 (26%) may have been eligible for fertility-sparing surgery such as cold-knife conization with pelvic lymph node dissection.

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Section: Introductionmentioning

confidence: 99%

Conservative surgery in early-stage cervical cancer: What percentage of patients may be eligible for conization and lymphadenectomy?

Smith

Frumovitz

Schmeler

et al. 2010

Gynecologic Oncology

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“…14 Prelabor rupture of the membranes occurred in 3 of 18 second-trimester cases, 4,6,8 1 at 26 weeks 6 and 2 after the 34th week of gestation. 4,8 Among the 18 patients operated on in the second trimester, significant prematurity less than 34 weeks occurred in only 2 pregnancies (29 and 26 weeks of gestation). 6,9 It has been demonstrated that the uterine arteries during vaginal radical trachelectomy (VRT) or ART may be preserved, and many techniques have been developed to conserve the ascending branches of the uterine arteries.…”

Section: Resultsmentioning

confidence: 99%

Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy: A Provocative Surgical Approach. Overview of the Literature and a Single-Institute Experience

Rodolakis

Thomakos

Sotiropoulou³

et al. 2018

Int J Gynecol Cancer

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ObjectiveTreatment of pregnancy complication due to malignancy of the cervix constitutes a great clinical challenge between optimal maternal therapy and fetal viability. Radical trachelectomy in early-stage cervical cancer during pregnancy instead of radical hysterectomy presents an alternative approach that can offer a satisfactory outcome for the mother and fetus.Materials and Methods–ResultsA literature search of articles in English has been performed. Until now, 28 women with cervical cancer, including 2 who were managed and treated in our institute, who underwent a radical trachelectomy during pregnancy have been reported. We overviewed a total of 13 abdominal trachelectomies, 13 vaginal trachelectomies, and 2 laparoscopic trachelectomies.ConclusionsRadical trachelectomy can widen the therapeutic approach of early-stage cervical cancer in pregnant women who wish to preserve their pregnancy, providing a possibility of receiving the proper treatment with no delay.

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“…Characteristic of this method, which was first described by Dargent et al (2), is the removal of parametrium inferior to the upper vagina. To avoid pregnancy termination by radical hysterectomy, radical trachelectomy is also used in pregnant women with early cervical cancer (7,8). However, there is no evidence that a radical trachelectomy is required for all early invasive cancers (9).…”

Section: Discussionmentioning

confidence: 99%

Simple trachelectomy of early invasive cervix carcinoma in the second trimester

Chvatal

Oppelt

Koehler

et al. 2011

J Turkish German Gynecol Assoc

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Although cervical carcinoma is among the most frequently encountered malignancies during pregnancy only a small number of cases during pregnancy have been reported. Usually, the patients have been treated by radical trachelectomy with or without chemotherapy during the pregnancy. Laparoscopic pelvic lymph node dissection with frozen section, simple trachelectomy and cerclage were performed in the 22 nd week of pregnancy. The histologic examination confirmed a squamous cell carcinoma of the cervix of 35mm diameter, lymphangioinvasion (L1), low grade, clear surgical margin, negative pelvic lymph nodes according to stage Figo IB. Adjuvant chemotherapy with three cycles of cisplatin was performed after surgery. Delivery was performed by cesarean section followed by radical hysterectomy in the the 32 nd week of pregnancy. Recurrent adjuvant chemotherapy with three cycles of cisplatin and local vaginal iridium radiation were performed after surgery. Patient had no surgery related complications. No relapse of cancer has been diagnosed during the following 16 months. Simple trachelectomy may be alternative treatment option to radical trachelectomy for pregnant women with early stage cervical cancer without lymph node metastasis. (J Turkish-German Gynecol Assoc 2011; 12: 121-3) Key words: Cervical cancer, pregnancy, trachelectomy, chemotherapy Received: 20 July, 2010 Accepted: 24 August, 2010 Servikal karsinoma gebelik süresince en sık karşılaşılan maligniteler arasında olmasına rağmen gebelik süresince olguların sadece küçük bir kısmı rapor edilmektedir. Genellikle, hastalar gebelik sırasında kemoterapi ile birlikte ya da kemoterapi olmaksızın radikal trakelektomi ile tedavi edilmektedir. Abstract ÖzetCase Report 121

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Radical abdominal trachelectomy in the 19th gestation week in patients with early invasive cervical carcinoma: case study and overview of literature

Cited by 37 publications

References 24 publications

Conservative surgery in early-stage cervical cancer: What percentage of patients may be eligible for conization and lymphadenectomy?

Conservative surgery in early-stage cervical cancer: What percentage of patients may be eligible for conization and lymphadenectomy?

Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy: A Provocative Surgical Approach. Overview of the Literature and a Single-Institute Experience

Simple trachelectomy of early invasive cervix carcinoma in the second trimester

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