In this paper, the first order radiative correction to the Casimir energy for a massive scalar field in the φ 4 theory on a spherical surface with S 2 topology was calculated. In common methods for calculating the radiative correction to the Casimir energy, the counter-terms related to free theory are used. However, in this study, by using a systematic perturbation expansion, the obtained counterterms in renormalization program were automatically position-dependent. We maintained that this dependency was permitted, reflecting the effects of the boundary conditions imposed or background space in the problem. Additionally, along with the renormalization program, a supplementary regularization technique that we named Box Subtraction Scheme (BSS) was performed. This scheme presents a useful method for the regularization of divergences, providing a situation that the infinities would be removed spontaneously without any ambiguity. Analysis of the necessary limits of the obtained results for the Casimir energy of the massive and massless scalar field confirmed the appropriate and reasonable consistency of the answers.