Radiation Toxicity in Patients With Collagen Vascular Disease: A Meta-Analysis of Case-Control Studies

Shaikh, P.; Singh, Sarah A.; Alite, Fiori; Vargo, John A.; Emami, Bahman; Wu, Meng-Jia; Jacobson, Geraldine M.; Bakalov, Veli; Small, William; Dahshan, Basem; Weir, Joshua; Renz, Paul; Harkenrider, Matthew M.

doi:10.1016/j.ijrobp.2021.08.006

Cited by 12 publications

(16 citation statements)

References 32 publications

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“…The combination of MTX and radiation therapy is said to potentially cause serious necrosis [7]. According to previous reports, a history of connective tissue diseases such as RA is suggested to be a risk factor for increasing radiation toxicity, which is believed to be involved in the necrosis of the pterygoid muscle in this case [8]. It has been reported that RA patients often have grade 5 complications, so complications should be carefully explained [8].…”

Section: Discussionmentioning

confidence: 99%

Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report

Miyamoto,

Sato,

Koike

et al. 2023

Case Rep Oncol

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Introduction: Radiation and intra-arterial cisplatin infusion chemotherapy (RADPLAT) for advanced maxillary sinus cancer has accumulated evidence as a treatment with fewer complications and better 5-year survival rates. In this study, we report a case in which pterygoid muscle necrosis occurred 6 months following RADPLAT treatment for maxillary sinus cancer. Case Presentation: The 45-year-old woman had a long history of taking immunosuppressants against rheumatoid arthritis (RA) prior to treatment. Although achieving complete response (CR) to RADPLAT, the patient developed trismus (1 fingerbreadth or less) 6 months following treatment. Abscess formation and recurrence were suspected from the imaging findings; however, the biopsy with endoscopy indicated necrotic tissue. Currently, 18 months have passed without cancer recurrence. Although trismus temporarily improved with rehabilitation, the width of the mouth opening is currently a few millimeters, so the patient can only take liquid food. Conclusion: Pterygoid muscle necrosis should be recognized as a new major complication.

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Section: Discussionmentioning

confidence: 99%

Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report

Miyamoto,

Sato,

Koike

et al. 2023

Case Rep Oncol

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“…No major landmark trials have established the efficacy and safety of SBRT for patients with stage I NSCLC and SADs. Shaikh et al performed a meta-analysis of 10 studies ( n = 4028 patients) and reported no significant differences in the OS, loco-regional recurrence-free survival, and distant metastasis-free survival between patients with collagen vascular disease (CVD) and the controls [ 19 ]. However, that study analyzed too many RT techniques and treatment sites.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings also revealed a poorer LCR in the SAD group. However, Diao et al and Shaikh et al reported no significant differences in the loco-regional recurrence-free survival between patients with CVD and the controls [ 19 ]. This difference may be due to the aforementioned reasons and our study’s homogeneous patient population.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed that a high proportion of patients with CVD who are irradiated to the breast, pelvis, or abdomen are associated with higher rates of radiation-induced toxicity [ 19 , 24 ]. Diao et al reported that patients with CVD had a significantly increased risk of RP after RT [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…They suggested that the incidence and severity of radiation toxicity may vary with the treatment site [ 24 ]. Shaikh et al also concluded that irradiated to the thorax had significantly higher rates of late G2/3+ radiation toxicity [ 19 ]. However, our findings indicated that there was no significant increase in the incidence of acute and late ≥G2 RP between the SAD and control groups, and toxicities should not be considered contraindications to SBRT.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Systemic Autoimmune Diseases on Treatment Outcomes and Radiation Toxicities in Patients with Stage I Non-Small Cell Lung Cancer Receiving Stereotactic Body Radiation Therapy: A Matched Case-Control Analysis

Chen

Nonaka

Oda

et al. 2022

Cancers

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We aimed to evaluate the impact of systemic autoimmune diseases (SADs) on treatment outcomes and radiation toxicities following stereotactic body radiation therapy (SBRT) for stage I non-small cell lung cancer (NSCLC). We queried an institution-based database on patients with SADs treated with SBRT for lung cancer between 2001 and 2016 (SAD group). Each patient was matched to three controls without SADs. The primary outcomes of interest were the overall survival (OS) and local control rate (LCR). The secondary outcomes were radiation toxicities of grades ≥2 (≥G2). Twelve patients with SADs were matched to 36 controls. The median follow-up duration was 3.6 years. There was a significant intergroup difference in the OS (hazard ratio [HR]: 4.11, 95% confidence incidence [CI]: 1.82–9.27, p < 0.001) and LCR (HR: 15.97, 95% CI: 2.89–88.29, p < 0.001). However, there were no significant intergroup differences in the odds of acute (odds ratio [OR]: 0.38, 95% CI: 0.02–8.91, p = 0.550) and late (OR: 2.20, 95% CI: 0.32–15.10, p = 0.422) ≥G2 radiation pneumonitis. No other ≥G2 toxicities were identified. In conclusion, although radiation toxicities are not enhanced by SADs, SADs are risk factors of poor prognosis following SBRT for stage I NSCLC.

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Local control strategies for management of NSCLC with oligoprogressive disease

Mavrikios,

Remon,

Quevrin

et al. 2023

Cancer Treatment Reviews

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Radiation Toxicity in Patients With Collagen Vascular Disease: A Meta-Analysis of Case-Control Studies

Cited by 12 publications

References 32 publications

Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report

Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report

Impact of Systemic Autoimmune Diseases on Treatment Outcomes and Radiation Toxicities in Patients with Stage I Non-Small Cell Lung Cancer Receiving Stereotactic Body Radiation Therapy: A Matched Case-Control Analysis

Local control strategies for management of NSCLC with oligoprogressive disease

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