Radiation Therapy Prophylaxis for Heterotopic Ossification in Non-Hip Sites

Patel, Ajay; Tzou, Katherine S.; Single, Megan Paige; Hollant, Laeticia; Smart, Bridget; Gaines, Katherine; Sherman, Courtney E.; Peterson, Jennifer; Ko, Stephen; Vallow, Laura A.; Miller, Robert C.; Buskirk, Steven J.

doi:10.4236/jct.2018.91001

Cited by 2 publications

(1 citation statement)

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“…Radiotherapy (RT) is proven to be effective in hip joint surgery [ 72 ], non-hip sites such as the elbow or knee [ 73 ], and NHO prophylaxis after spinal cord injury [ 74 ]. RT is administered before surgery or within 72 h after surgery [ 75 ].…”

Section: Introductionmentioning

confidence: 99%

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

et al. 2022

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Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic (acquired) background, that is, it could be caused by musculoskeletal trauma, such as burns, fractures, joint arthroplasty (traumatic HO), or cerebral or spinal insult (neurogenetic HO). HO formation is caused by the differentiation of stem or progenitor cells induced by local or systemic imbalances. The main factors described so far in HO induction are TGFβ1, BMPs, activin A, oncostatin M, substance P, neurotrophin-3, and WNT. In addition, dysregulation of noncoding RNAs, such as microRNA or long noncoding RNA, homeostasis may play an important role in the development of HO. For example, decreased expression of miRNA-630, which is responsible for the endothelial–mesenchymal transition, was observed in HO patients. The reduced level of miRNA-421 in patients with humeral fracture was shown to be associated with overexpression of BMP2 and a higher rate of HO occurrence. Down-regulation of miRNA-203 increased the expression of runt-related transcription factor 2 (RUNX2), a crucial regulator of osteoblast differentiation. Thus, understanding the various functions of noncoding RNAs can reveal potential targets for the prevention or treatment of HO.

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Section: Introductionmentioning

confidence: 99%

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

et al. 2022

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Prophylaxis for Heterotopic Ossification Following Distal Biceps Tendon Repair

Antonacci¹,

Brown²,

O’Brien³

et al. 2021

Orthopedics

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Heterotopic ossification (HO) is a possible complication of distal biceps tendon repair (DBTR). Several agents can prevent HO formation, although relatively few studies have investigated prophylaxis specifically after DBTR. The purposes of this study were to survey members of the American Shoulder and Elbow Surgeons (ASES) to determine (1) what percentage use HO prophylaxis after DBTR; (2) type, dosage, and duration of prophylaxis used; and (3) use of single-incision or double-incision surgical technique. An anonymous electronic survey was distributed to ASES members to determine the use of HO prophylaxis and DBTR technique. The survey included questions regarding the number of DBTRs performed annually; preferred surgical technique and implants; and type, dosage, and duration of HO prophylaxis used before, during, and after surgery. Descriptive statistics were used to analyze the results. Of 173 respondents, 98 (56.6%) performed 1 to 10 DBTRs per year, 65 (37.6%) performed 11 to 25 DBTRs per year, and 10 (5.8%) performed 26 to 50 DBTRs per year. A total of 131 (75.7%) preferred the single-incision technique, whereas 42 (24.3%) preferred the double-incision technique. A total of 94 (54.3%) performed DBTR using a metal button and interference screw, 35 (20.2%) through drill holes, 25 (14.5%) with suture anchors, and 19 (11.0%) with a metal button alone. A total of 132 (76.3%) respondents did not use HO prophylaxis, and 41 (23.7%) used nonsteroidal anti-inflammatory drugs following surgery. A total of 35 (85.4%) used indomethacin, 18 (51.4%) of whom preferred 75 mg/d for 3 to 4 weeks. Heterotopic ossification is a commonly reported complication following DBTR, especially with the double-incision technique. Prophylaxis with anti-inflammatory medications and suppressive modalities (radiation therapy) appear to reduce the incidence of HO. Despite these data, most surgeons (76.3%) do not use HO prophylaxis. Low annual volume of cases, lack of large-volume studies with outcome data, and the dominant use of the single-incision repair technique may explain this. [ Orthopedics . 2021;44(4):e588–e592.]

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Radiation Therapy Prophylaxis for Heterotopic Ossification in Non-Hip Sites

Abstract: Background: Radiation therapy prophylaxis for heterotopic ossification is well-established for the hip, either pre or post-operatively. There is limited data for this treatment in non-hip sites. We report our institution's experience. Methods: From

Cited by 2 publications

References 19 publications

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

Prophylaxis for Heterotopic Ossification Following Distal Biceps Tendon Repair

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