Radiation Therapy of Brain-Stem Tumors

Whyte, Thomas R.; Colby, Malcolm Y.; Layton, Donald D.

doi:10.1148/93.2.413

Cited by 44 publications

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“…Since 1939, B ailey et al [1] [7], and Sieben and Ishii [9], They all agree on the variety of the clinical picture, the absence of signs of intracranial hypertension and the abnormal dimensions of the brain stem, as shown by ventriculo graphy.Interesting contributions about the results of radiation therapy were reported by R admond [8] and W hite et al [11], Finally, L assiter et al[5] published a work with a clearly provocative title about the surgical treatment of brain stem tumors. In 5 out of these 34 explored patients cystic tumors were found and partially removed.…”

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confidence: 99%

Follow-Up Study of Brain Stem Tumors in Children

1975

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In a series of 180 patients affected by brain stem tumors, 70 cases of children up to 16 years are analyzed. Diagnosis was made with clinical examinations, neuroradiological tests and, in 20 cases, with surgical explorations. A description is made concerning the clinical status with regard to site, extension and features of the tumor. Then the authors analyze statistically the survival of such patients in connection with clinical symptomatology, the radiological picture, medical treatment, radiation and/or surgical therapy either in the few cases of subtotal removal of the tumors, or in the more numerous cases of palliative procedures such as intra- and extrathecal CSF shunting.

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confidence: 99%

Follow-Up Study of Brain Stem Tumors in Children

1975

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“…Intraoperatively the patient had no conspicuous vegetative reactions, the continuously recorded evoked potentials showed no change. Looking at the literature, at least concerning gliomas the results give no unequivocal particulars of any real improvement in the survival time (4,39,54,56,64,69). No significant change of the other symptoms.…”

Section: Treatmentmentioning

confidence: 84%

“…The frequency of instrinsic brain stem tumours is stated in the literature as being between 2% and 12% of all brain tumours (69). All authors emphasize the frequency of these tumours in childhood and adolescence, where a frequency of up to 20% is given (Hara et al 7.8%, Redmond 10-15%, Teilman 10%, Fulton et al 10-20%).…”

Section: Treatmentmentioning

confidence: 99%

Brain stem tumours — diagnosis and surgical treatment

Schönmayr¹,

Agnoli

1983

Neurosurg. Rev.

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The diagnosis of brain stem tumours is mainly based on clinical findings and CT examinations: The CT examination including intravenous or intrathecal administration of contrast media together with electronic image-reconstruction greatly influences the indications for direct operation. According to our interpretation, direct surgical treatment is apparently successful under the following circumstances: - in tumours with external growth, which allows a decompression of the tumour without harming the surrounding structures in the brain stem. - in tumours with a marked cystic component, especially if the compressive effect is causing the features and progress of the symptoms.

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“…Whyte et al [21] found an improvement in S-year survival with doses greater than 40 Gy. Kim 1421 and Lee et al…”

Section: Selection Of the Radiation Therapy Treatment Volume And Dosementioning

confidence: 94%

Selection of a management strategy for pediatric brainstem tumors

Halperin

Wehn

Scott

et al. 1989

Med. Pediatr. Oncol.

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Brainstem tumors arise in portions of the rhombencephalon and mesencephalon. Some authorities include diencephalic tumors in this group. We have reviewed our clinical experience of 69 children (less than 21 years of age) with brainstem tumors evaluated and treated at Duke University Medical Center (DUMC) from 1960 to 1986. There were 19 patients with group 1 tumors (thalamus, third ventricle region, or midbrain) and 50 with group II tumors (pons, medulla oblongata). The common presenting signs and symptoms were ataxia, headache, motor loss, and cranial nerve palsies. The most commonly employed diagnostic imaging studies were air examinations and CT. Preradiotherapy confirmation of malignancy was obtained in five group I patients (astrocytoma, 4; germinoma, 1) and 8 group II patients (astrocytoma, 3; anaplastic astrocytoma, 2; glioblastoma multiforme, 3). All patients received radiotherapy. The 5-year survival rate for the entire population was 40%. The survival rate for group I patients was significantly better than that observed for group II patients. In the 50 group II patients neither patient sex nor age nor presence of cranial nerve palsies nor pretreatment CT scan findings nor field size influenced survival. A long duration of symptoms positively influenced survival. The vast majority of tumor recurrences were within the radiation field. Half of the patients had either stable or improved Karnofsky status 6 months following completion of irradiation. The management strategy for childhood brainstem tumors is discussed.

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Radiation Therapy of Brain-Stem Tumors

Cited by 44 publications

References 0 publications

Follow-Up Study of Brain Stem Tumors in Children

Follow-Up Study of Brain Stem Tumors in Children

Brain stem tumours — diagnosis and surgical treatment

Selection of a management strategy for pediatric brainstem tumors

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