Radiation Therapy of Adult T-Cell Leukemia

Baba, Yuji; Arakawa, Akihiko; Furusawa, Mitsuhiro; Murakami, Ryuji; Matsubara, Y; Takahashi, Manabu; Johno, Masayoshi; Ono, T; Takatsuki, Kiyoshi

doi:10.3109/02841869409121780

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…In their 5-patient series, total clinical resolution of nodal disease occurred with 30 Gy. 16 In their subsequent report of 30 patients treated with radiotherapy from 1983 to 1991, patients received highenergy x-rays, cobalt-60 ␥ rays, or electrons to 10.8-40.0 Gy in 1.5-to *Disease status at the time of patient mortality. †Patients with new out-of-field disease, as opposed to patients with out-of-field progression of disease that was evident before starting radiation therapy.…”

Section: Toxicitymentioning

confidence: 99%

“…Nodal patients were less likely to respond (69%) and had a 5.4-month mean survival. 17 Unlike with that cohort, the present study used modern radiotherapy treatment planning strategies to treat all fields each treatment day, administering daily fractions, using more standard fraction sizes of 2-3 Gy, and using all linear accelerator-based therapy rather than older cobalt-60 equipment. Radiotherapy is well tolerated and can achieve excellent local control and universal symptomatic improvement in patients with ATL.…”

Section: Toxicitymentioning

confidence: 99%

“…Only 1 prior case series of patients with ATL treated over 20 years ago used localized external beam radiotherapy. 16,17 We report a patient series treated with modern radiotherapy techniques to assess the role of external beam radiotherapy for ATL. We evaluated symptomatic response and local control in these patients.…”

Section: Introductionmentioning

confidence: 99%

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Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma

Simone

Morris

Stewart

et al. 2012

Blood

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Section: Toxicitymentioning

confidence: 99%

Section: Toxicitymentioning

confidence: 99%

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Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma

Simone

Morris

Stewart

et al. 2012

Blood

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“…To the best of our knowledge, only two prior case series of patients with ATL treated with RT have been published. One of the studies included 30 patients treated more than 25 years ago using an older radiation technique [13], and the other reported the effectiveness of RT for local control of ATL with a modern radiation technique in 2012. However, the number of patients in the latter study was only 10 [11].…”

Section: Introductionmentioning

confidence: 99%

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma

Maemoto¹,

Ariga

Nakachi

et al. 2018

Journal of Radiation Research

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Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that occurs only in patients with human T-cell leukemia virus type 1. No large study or randomized trial investigating radiotherapy (RT) for ATL has been performed. We retrospectively reviewed 55 courses of RT for 41 consecutive patients with ATL who underwent RT between 2000 and 2016 at our institutions. The results showed that RT for local ATL lesions can achieve symptomatic improvement in 92% of cases. Local remission, either complete remission (CR) or partial response (PR), was achieved in 100% of the patients (CR: 89%, PR: 11%) with ≥40 Gy irradiation. CR or PR was achieved in 71% (CR: 29%, PR: 43%) with 30-39 Gy and in 73% (CR: 6.7%, PR: 67%) with ≤29 Gy irradiation. The mean total radiation dose in the CR and PR groups differed significantly (38 vs 25 Gy, P = 0.0002). The maximum acute toxicity was Grade 0-2 in all patients, except for one patient experienced Grade 3 radiation dermatitis. In-field relapses occurred in 36% of patients, and the frequency of in-field relapses was 11%, 30% and 71% among those who achieved CR, PR and SD, respectively. All 9 patients who received total skin irradiation experienced cutaneous relapses, with a median of 63 days (range, 7-210 days). Almost all (39 of 41) patients with ATL experienced out-of-field progression after RT. In conclusion, RT was confirmed to be effective and safe for palliative treatment of local ATL lesions.

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Current Status of Therapeutic Approaches to Adult T-Cell Leukemia

Ishikawa

2003

Int J Hematol

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More than 2 decades have elapsed since the proposal of adult T-cell leukemia (ATL). Since then, the discovery of the etiologic virus, human T-cell leukemia virus type I (HTLV-I), and the establishment of the diagnostic steps of serum test and molecular study have clearly defined ATL as a distinct disease entity. Because conventional chemotherapy, which is active against other lymphoid malignancies, was proven to be ineffective for treating aggressive forms of ATL, ATL has become the target of several clinical studies for the purpose of improving therapeutic outcomes. Combination chemotherapy exclusively designed for ATL has considerably elevated the treatment response rate in ATL patients, but it has not sufficiently extended the median survival time. The introduction of antiviral agents has led to surprising effects for patients with acute ATL. Monoclonal antibodies seem to be promising, especially for patients with chemotherapy-resistant disease. Unfortunately, these approaches did not prove to be sufficient for most patients with ATL to obtain long-term survival. Recent promising reports on allogeneic stem cell transplantation (allo-SCT) for ATL have suggested that allo-SCT could overcome the limitations that other treatment modalities have not surmounted. More efforts are clearly needed to clarify the usefulness of allo-SCT, especially with reduced-intensity conditioning regimens, for ATL patients.

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Radiation Therapy of Adult T-Cell Leukemia

Cited by 6 publications

References 5 publications

Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma

Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma

Current Status of Therapeutic Approaches to Adult T-Cell Leukemia

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