Radiation Therapy Is Associated With Improved Survival in the Adjuvant and Definitive Treatment of Intrahepatic Cholangiocarcinoma

Impact of adjuvant chemoradiation on survival in patients with resectable cholangiocarcinoma

“…26 Our results are further in line with two large database studies: Abott et al recently analyzed a national cancer database (n = 8741) demonstrating a benefit in OS with adjuvant CRT after surgical resection of extrahepatic CC regardless of margin status, 27 and a retrospective SEER analysis of patients with intrahepatic CC (n = 3839) showed an OS benefit of five months with adjuvant RT (n = 269) as compared to surgery alone (n = 960). 15 As opposed these large national database inquiries which lack not only specifics of therapy but also in-depth demographic and tumor detail, our results provide an inclusive analysis of a number of clinicopathologic factors potentially at play.…”

“…13 The high rate of local recurrence following resection suggests the need for aggressive adjuvant therapy, though few studies have addressed this issue to date. A few retrospective series have shown benefits in both local control and improved overall survival when using radiation therapy (RT) for unresectable CC, [14][15][16][17][18] establishing its activity in this disease. Adjuvant chemotherapy (CT) and/or concurrent chemoradiation (CRT) for resected CC has also been associated with increased survival in pooled meta-analyses of historic international series, especially in those with involved lymph nodes or microscopic residual disease following resection.…”

WITHDRAWN: Defining the Role of Adjuvant Therapy: Cholangiocarcinoma and Gallbladder Cancer

“…28 Adjuvant RT was associated with a survival improvement over observation, with a median survival of 11 months for patients receiving adjuvant radiation compared with 6 months for those who were observed (P ¼ 0.014). After propensity score adjustments for age, race, stage, and year of diagnosis, the authors still found significant improvements with adjuvant radiation (hazard ratio ¼ 0.82) compared with observation.…”

Clinical analysis of cholangiocarcinoma patients receiving adjuvant radiotherapy

“…However, radiation as an adjuvant or palliative treatment appears to confer a survival advantage in patients with intra-or extrahepatic CCA (22,24,33,34). Radiotherapy has been shown to prolong patient survival by ~4 months in unresectable intrahepatic CCA (35).…”

“…For patients with resectable CCA, the effectiveness of postoperative adjuvant radiotherapy remains controversial, as diverse studies report either positive or null results. Although the debate regarding the benefit of radiotherapy for patients with CCA is ongoing, certain factors have been shown to affect treatment outcomes and patient survival (18,(22)(23)(24)(25)(26). Age, ethnicity, tumor stage and year of diagnosis, as the numbers of patients receiving radiotherapy were growing, have been associated with the prognosis of CCA patients following radiotherapy (22).…”