Radiation therapy in the unresectable cavernous hemangioma of the liver

Gaspar, Luís; Mascarenhas, F.; Costa, Mariana Reis; Dias, Josiane Mourão; Afonso, J G; Silvestre, Mattia

doi:10.1016/0167-8140(93)90172-5

Cited by 67 publications

(41 citation statements)

References 37 publications

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“…For symptomatic patients and/or hemangiomas larger than 5cm, several approaches had been studied. Non-surgical options included hepatic arterial embolization, [8] radiation [9], or interferon alpha-2a [10]. Enucleation was currently the preferred surgical treatment, followed by liver resection [4].…”

Section: Discussionmentioning

confidence: 99%

Pedunculated Hepatic Hemangiomas often Misdiagnosed Despite Their Typical Findings

Ha¹

2013

TOSJ

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Abstract:Background: Hepatic hemangiomas are the most common benign liver tumors which can be often diagnosed radiologically. However despites their typical radiologic findings, giant pedunculated hemangiomas are rare and often misdiagnosed as a supra-renal, retroperitoneal, gastric, or mesenteric mass. Methodology:The authors present a case and the summary of a thorough literature search on this rare disease entity.Results: A 35-year-old male is found to have a 12cm mesenteric mass on computed tomography and undergoes a surgical exploration. Intraoperatively, a large pedunculated hepatic hemangioma from the left lobe of the liver is encountered and removed successfully. A thorough PubMed search reveals a total of 18 publications in English with 24 cases of giant pedunculated hepatic hemangioma, most of which occur in older females, and originate from the left lobe of the liver. These tumors in general retain the typical computed tomography or magnetic resonance imaging findings of an intrahepatic hemangioma.Conclusions: When a peri-hepatic lesion possesses typical radiologic characteristics of a hemangioma, pedunculated hemangioma should be included in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Pedunculated Hepatic Hemangiomas often Misdiagnosed Despite Their Typical Findings

Ha¹

2013

TOSJ

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“…However, only short-term control could be achieved for hepatic hemangiomas. [13][14][15][16][17][18] Since the 1990s, radiofrequency ablation (RFA) has been applied successfully to treat hepatic hemangiomas. However, due to the limitations of the RFA equipments and electrodes, the effectiveness, safety and feasibility of percutaneous RFA remain controversial for hepatic hemangiomas of ≥5 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

Efficacy, safety and feasibility of ultrasound‐guided percutaneous microwave ablation for large hepatic hemangioma

Tang

Wang

et al. 2015

J of Digest Diseases

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OBJECTIVE:To evaluate the efficacy, safety and feasibility of microwave ablation (MWA) for large (5-10 cm in diameter) hepatic hemangioma. METHODS:In all, 46 patients with 47 large hepatic hemangiomas were treated with ultrasound-guided percutaneous MWA. The effect of MWA for all patients was evaluated by enhanced magnetic resonance imaging or computed tomography within two months after ablation. RESULTS:A total of 27 male and 19 female patients were enrolled, with an average age of 46 ± 11 years. The average size of hemangiomas was 6.3 ± 1.4 cm (range 5.0-9.6 cm). The initial complete ablation rate was 91.5% (43/47) and the volume of ablated lesions was significantly reduced. The rate of complete necrosis was not associated with the tumor size or location (P = 0.899 and 0.758, respectively). The total complete ablation rate was 95.7% (45/47). Major complications included acute renal dysfunction, hyperbilirubinemia and pleural effusion. No procedure-related death occurred. The average hospitalization stay was 5.7 ± 2.5 days (range 3-17 days). During a follow-up period of 18.2 months (range 4-40 months), one patient developed local tumor progression at the radiofrequency ablation site. Three patients had new hemangiomas in other sites of the liver. At the end of the study all patients were alive and no severe complications occurred. CONCLUSION:Image-guided MWA is an effective and safe treatment for large hepatic hemangiomas, and can potentially be regarded as the first-line therapy.

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“…Surgical resection is the definitive treatment of large hemangiomas, while other less effective options include arterial ligation or embolization, radiation therapy, and percutaneous ablation techniques (4,15,(17)(18)(19). Radiation therapy can reduce the size of the lesion; however, its longterm effects on the liver and adjacent structures may be deleterious (15,17).…”

Section: Discussionmentioning

confidence: 99%

“…Radiation therapy can reduce the size of the lesion; however, its longterm effects on the liver and adjacent structures may be deleterious (15,17). Experience on the treatment of hemangiomas with percutaneous ablation techniques has been limited in the literature.…”

Section: Discussionmentioning

confidence: 99%