Radiation therapy in the treatment of malignant fibrous histiocytoma

Reagan, Morris T.; Clowry, Lawrence J.; Cox, James D.; Rangala, Nalinakshi

doi:10.1016/0360-3016(81)90103-6

Cited by 25 publications

(6 citation statements)

References 23 publications

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“…The prognosis is strongly dependent on tumor size and the depth of a muscular tumor [ 24 , 25 ]. Complete surgical resection at the time of primary tumor presentation is the treatment of choice, although adjuvant radiation therapy plays an important role in achieving better local control [ 25 – 27 ]. Responses to primary single and combination chemotherapy occur in about 30% of the patients [ 24 ].…”

Section: Radiation Response By Histologic Subtypementioning

confidence: 99%

“…A literature survey in 1981 revealed that local control was obtained in only 2 of 16 patients treated by radiotherapy alone, but measurement of tumor response or details of the radiation treatment were not well documented [ 27 ]. A study of 16 patients with measurement of the radiation response in malignant fibrous histiocytomas came from the Princess Margaret Hospital in Toronto.…”

Section: Radiation Response By Histologic Subtypementioning

confidence: 99%

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The Radiation Response of Sarcomas by Histologic Subtypes: A Review With Special Emphasis Given to Results Achieved With Razoxane

Rhomberg¹

2006

Sarcoma

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Purpose. Relatively few results are available in the literature about the radiation response of unresectable sarcomas in relation to their histology. Therefore, an attempt was made to summarize the present situation. Materials and methods. This report is based on a review of the literature and the author's own experience. Adult-type soft tissue sarcomas, chondrosarcomas, and chordomas were analyzed. Radioresponse was mainly associated with the degree of tumor shrinkage, that is, objective responses. Histopathologic responses, that is, the degree of necrosis, are only discussed in relation to radiation treatment reports of soft tissue sarcomas as a group. Results. Radiation therapy alone leads to major responses in about 50% of lipo-, fibro-, leiomyo-, or chondrosarcomas. The response rate is less than 50% in malignant fibrous histiocytomas, synovial, neurogenic, and other rare soft tissue sarcomas. The response rates may increase up to 75% through the addition of radiosensitizers such as halogenated pyrimidines or razoxane, or by the use of high-LET irradiation. Angiosarcomas become clearly more responsive if biologicals, angiomodulating, and/or tubulin affinic substances are given together with radiation therapy. Razoxane is able to increase the duration and quality of responses even in difficult-to-treat tumors like chondrosarcomas or chordomas. Conclusions. The available data demonstrate that the radioresponsiveness of sarcomas is very variable and dependent on histology, kind of radiation, and various concomitantly given drugs. The rate of complete sustained remissions by radiation therapy alone or in combination with drugs is still far from satisfactory although progress has been made through the use of sensitizing agents.

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Section: Radiation Response By Histologic Subtypementioning

confidence: 99%

Section: Radiation Response By Histologic Subtypementioning

confidence: 99%

The Radiation Response of Sarcomas by Histologic Subtypes: A Review With Special Emphasis Given to Results Achieved With Razoxane

Rhomberg¹

2006

Sarcoma

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“…In a well-documented series, Reagan et al [7] treated 17 patients who had MFH of the trunk and extremities with high-dose radiotherapy (median dose, 60 Gy in 43 days). Locoregional control was achieved in 2 out of 5 unresectable lesions and in 9 out of 12 radical-surgery patients.…”

Section: Discussionmentioning

confidence: 99%

“…The actual role exercised by radiotherapy in our patients might be queried, in view of the fact that three cycles of chemotherapy were sufficient to achieve a major objective response. However, the results of Reagan et al [7] bear out the value of irradiation in lasting locoregional control, if one considers that local recurrence was prevented in three patients with resection margins infiltrated by microscopic tumor and in two out of three patients with questionable margins. Furthermore, the possible synergistic effect between Adriamycin and irradiation [15] should be taken into account.…”

Section: Discussionmentioning

confidence: 99%

Unresectable retroperitoneal malignant fibrous histiocytoma: Prolonged complete remission following chemoradiotherapy

Tucci

Leoncini

Pirtoli

et al. 1988

Journal of Surgical Oncology

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Two cases of unresectable retroperitoneal malignant fibrous histiocytoma (MFH) achieving a prolonged complete remission by a combination of chemotherapy (adriamycin plus cyclophosphamide) and abdominal irradiation are reported. Although an optimal treatment policy for such cases has not been established, on the basis of data currently available, chemotherapy regimens including anthracyclines seem the most reliable therapeutic approach in unresectable and/or metastatic MFH.

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“…The treatment of recurrent disease is difficult. Prophylactic postoperative radiotherapy may reduce the rate of local recurrence (Pillay et al, 1980) and irradiation has controlled pulmonary secondaries (Reagan et al, 1981), but chemotherapy produced a partial response in only one third of patients with metastases (Leite et al, 1977) and both modes of treatment require further evaluation.…”

Section: Discussionmentioning

confidence: 99%