Radiation Therapy in Peyronieʼs Disease

Ww, Helvie; Sf, Ochsner

doi:10.1097/00007611-197210000-00007

Cited by 32 publications

(4 citation statements)

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“…However, it lacks the evidence-based information to be used for treatment of PD. Improvement of patients treated with orthovoltage therapy was reported [82,83] . Additional reported benefits are low expenses, minimal side effects and immediate effectiveness.…”

Section: Radiotherapymentioning

confidence: 99%

Conservative treatment for Peyronie's disease: an update

El‐Sakka

Yassin

2007

Expert Opinion on Pharmacotherapy

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Many theories have been proposed to explain the cause of Peyronie's disease (PD); however, the true pathogenesis of PD remains an enigma. As a result, the treatment of PD remains a dilemma and new therapies continue to evolve. The last two decades have witnessed a phenomenal advance in the understanding of the pathophysiology and natural history of PD. The efficacy of conservative treatment for PD is not settled. In this update review the authors provide information of the status of conservative therapy for PD. Conservative treatment is always the initial treatment in most of the cases. This kind of therapy consists of different modalities of treatment such as oral, intralesional or topical therapy. Other treatments including iontophoresis, extracorporeal shock wave, radiotherapy, ultrasound and laser have also been reported.

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Section: Radiotherapymentioning

confidence: 99%

Conservative treatment for Peyronie's disease: an update

El‐Sakka

Yassin

2007

Expert Opinion on Pharmacotherapy

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“…The mechanism of action of radiotherapy in PD was proposed through its effective anti‐inflammatory action and upregulation of NO 131 . Improvement of patients with active PD treated with orthovoltage therapy was reported 132,133 . In additional to low expenses and immediate effectiveness, however, the safety and benefits of radiotherapy in such condition are questionable 134,135 .…”

Section: Methodsmentioning

confidence: 99%

Medical, non‐invasive, and minimally invasive treatment for Peyronie’s disease: A systematic review

El‐Sakka

2020

Andrology

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Background The treatment of Peyronie's disease (PD) remains a dilemma as the true pathogenesis of PD remains an enigma. Consequently, new molecules and therapies continue to evolve. The safety and efficacy of conservative treatment for PD have not yet established. Objectives To provide the available information of the status of conservative therapy for PD. Methods A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library for English‐language journal articles between January 2000 and July 2019, using the terms “Conservative treatment for PD”, “medical treatment for PD”, “non‐invasive therapies for PD” and “minimally invasive therapies for PD". This systematic review was conducted in agreement with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) system. We also manually reviewed references from selected articles. The risk of bias in the included RCTs was assessed using the Cochrane Risk of Bias Assessment tool (RoB 2). Results Conservative treatment is accepted as the initial treatment step in most of the cases. This kind of therapy includes various methods of treatment such as medical, non‐invasive, and minimally invasive therapies. Ideal management of PD is not yet available. It is not possible to assess the value of treatment without well‐designed, randomized, placebo‐controlled, large‐scale clinical studies. Conclusion Optimistically, in the near future, we may witness emergence of efficacious new agents and modalities to revolutionize medical, non‐invasive, and minimally invasive treatment of this devastating condition.

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“…Eightythree percent of patients reported that penile pain was diminished or disappeared, 23% reported improvement in penile curvature, and erectile function improved in 8%. With respect to their [32] 1967 12 X-Ray N/A Dunlap and Lathem [33] 1969 47 Orthovoltage N/A Helvie and Ochsner [34] 1972 40 Orthovoltage N/A Furlow et al [21] 1975 177 Orthovoltage N/A Mira et al [35] 1980 56 Orthovoltage N/A Carson and Coughlin [36] 1985 40 Orthovoltage N/A Weisser et al [37] 1987 54 Electrons N/A Bittard et al [38] 1988 93 Orthovoltage N/A Viljoen et al [39] 1993 98 Orthovoltage Presence/absence of intercourse* Rodrigues et al [40] 1995 38 Orthovoltage radiotherapy † Improved sex life* Koren et al [41] 1996 265 Iridium moulage N/A Incrocci et al [42] 2000 179 Orthovoltage X-rays or electrons 15-item questionnaire Meineke et al [43] 2003 67 Soft X-rays N/A Niewald et al [44] 2006 154 Gamma rays/photon beams/electron beams Presence of ED postradiation* *Single-item questions † In combination with vitamin E current sex life, 51% reported sometimes or always having problems getting an erection and 61% had problems with maintaining an erection, while 36% never experienced spontaneous erections. Pretreatment, only 72% of patients were sexually active, with no specific pretreatment questionnaire used in this study.…”

Section: Outcomes Of Rt In Pd Patientsmentioning

confidence: 99%

Radiation Therapy in Peyronie’s Disease

Mulhall¹,

Hall²,

Broderick³

et al. 2012

The Journal of Sexual Medicine

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Introduction Peyronie’s disease (PD) is characterized by fibrotic plaque formation within the tunica albuginea, leading to penile deformity, angulation, painful erections, and often, erectile dysfunction. There is limited knowledge of its etiology and pathophysiology. Currently, there is no standardization for reporting the evaluation and treatment outcomes. No consensus exists on the ideal management of PD. Aim The aim of this study is to review the use of radiation therapy (RT) for the treatment of PD. Methods This study used a review of the literature and informed expert opinion. Main Outcome Measures The main outcome measures are the reported improvement with regard to pain, curvature, plaque size, and erectile function as well as a review of the safety profile of RT. Results Radiation has been used for the empirical treatment of PD with mixed results throughout the literature. Low-dose RT in the early stages of PD seems to be effective in patients with painful erections not improving with time or with the use of oral or intralesional therapies. Comparison with other current medical therapies is difficult due to the absence of criteria for therapeutic success and the absence of randomized, controlled trials. Multiple studies have demonstrated varied results in terms of curvature reduction, plaque volume, and sexual functioning. The absence of the use of validated means of measuring penile deformity and sexual function, the limited relevance of plaque and pain improvement combined with the potential negative consequences of radiation on erectile tissue structure and function lead us to make a recommendation that RT not be used for the management of PD. Conclusions In clinical practice, mixed success for RT has led to the recommendation against its use as a treatment modality for PD.

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Radiation Therapy in Peyronieʼs Disease

Cited by 32 publications

References 0 publications

Conservative treatment for Peyronie's disease: an update

Conservative treatment for Peyronie's disease: an update

Medical, non‐invasive, and minimally invasive treatment for Peyronie’s disease: A systematic review

Radiation Therapy in Peyronie’s Disease

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