Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors

Shioyama, Yoshiyuki; Nakamura, Katsumasa; Ohga, Shouichi; Nomoto, Satoshi; Sasaki, Takahiro; Yamaguchi, Toshihiro; Toba, Takashi; Yoshitake, Tsuyoshi; Terashima, Hiromi; Honda, Hiroshi

doi:10.1093/jjco/hym138

Cited by 50 publications

(60 citation statements)

References 15 publications

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“…Improvement of symptoms with an objective response rate of 65-91% has been reported in several studies [5,15,16]. In our study, an objective improvement of symptoms was observed in 68% of patients, which is in line with other reports.…”

Section: Discussionsupporting

confidence: 93%

“…Nemoto et al [16] reported that 1 patient (3%) died of necrosis of the gastric tube 6 months after an RT dose of 66 Gy. Shioyama et al [5] observed no significantly survival difference between the REC patients treated with 60 Gy or more and those treated with less than 60 Gy (p = 0.10), but a significant difference between doses <50 Gy and ≥ 50 Gy (p = 0.04). In our series, patients who were treated with conformal RT had a longer survival compared to those with conventional plan.…”

Section: Discussionmentioning

confidence: 95%

“…Radio(chemo)therapy has been reported to have beneficial effects on symptomatic control and might facilitate long-term survival in some patients with REC [5,8]. It must, therefore, be considered as an important tool for palliative or curative treatment in REC.…”

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confidence: 99%

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Salvage radiotherapy in patients with recurrent esophageal carcinoma

et al. 2012

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RT is feasible and effective in the management of recurrent esophageal carcinoma, especially for relief of symptoms. Toxicity is in an acceptable range. The outcome of REC is poor; however, long-term survival of patients with recurrent esophageal carcinoma after radiochemotherapy might be possible, even with a previous history of radiotherapy in the initial treatment. If re-irradiation of esophageal carcinoma is contemplated, three-dimensional conformal techniques and a minimum total dose of 45 Gy are recommended.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

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Salvage radiotherapy in patients with recurrent esophageal carcinoma

et al. 2012

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“…Factors such as the time to recurrence, number of recurrent tumors, tumor size, presence of distant organ recurrence, the administration of preoperative therapy and lack of treatment for recurrence have been reported to be risk factors for a dismal post-recurrence survival [9][10][11][12][13] . In this study, we investigated the value of these factors in predicting the prognosis after recurrence.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors for Post-Recurrence Survival in Patients with Thoracic Esophageal Squamous Cell Carcinoma after Curative Resection

Nakajima

Kawada²,

Tokairin³

et al. 2016

Dig Surg

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Background/Aims: We investigated factors affecting the post-recurrence prognosis in order to develop adequate therapeutic guidelines for determining the indication for treatment of recurrent esophageal squamous cell carcinoma (ESCC). Methods: Ninety-three thoracic ESCC patients who developed postoperative recurrence after undergoing curative esophagectomy with 3-field lymphadenectomy at our institute and who received treatment for recurrence were enrolled in this study. Results: A univariate analysis showed that distant organ recurrence, the number of recurrent tumors, the longest diameter of the largest recurrent tumor, the sum of all of the longest diameters of the recurrent tumors, invasion into adjacent structures and the speed of growth of the representative recurrent tumors were significantly associated with the post-recurrence prognosis. A multivariate analysis showed that distant organ recurrence, the longest diameter of the largest recurrent tumor, invasion into adjacent structures and the speed of growth of the representative recurrent tumors were significantly associated with the prognosis. The patients whose recurrent tumor(s) did not meet all 4 of these factors showed a better prognosis. In contrast, the prognosis of the patients whose recurrent tumor(s) demonstrated all 4 factors was almost the same as that observed in the patients who did not receive any treatment for recurrence. Conclusions: The evaluation of these 4 factors may potentially be used to determine the indication for treatment for recurrence.

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“…However, long-term survival might be expected by definitive radiotherapy for the patients with small-size tumors and with a good performance status [25] . Raoul et al [26] reported the survival rates of patients with postoperative recurrence treated with chemoradiotherapy to be 47.1% at one year, 17.1% at two years and 4.3% at three years.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of¹⁸F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy

Sun¹,

X²,

Guan³

et al. 2009

WJG

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Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors

Abstract: The prognosis of patients with post-operative loco-regional recurrence of esophageal cancer is poor. However, a long-term survival may be expected by definitive radiotherapy for the patients with small-size tumors and with a good PS.

Cited by 50 publications

References 15 publications

Salvage radiotherapy in patients with recurrent esophageal carcinoma

Salvage radiotherapy in patients with recurrent esophageal carcinoma

Prognostic Factors for Post-Recurrence Survival in Patients with Thoracic Esophageal Squamous Cell Carcinoma after Curative Resection

Clinical usefulness of¹⁸F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy

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Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors

Abstract: The prognosis of patients with post-operative loco-regional recurrence of esophageal cancer is poor. However, a long-term survival may be expected by definitive radiotherapy for the patients with small-size tumors and with a good PS.

Cited by 50 publications

References 15 publications

Salvage radiotherapy in patients with recurrent esophageal carcinoma

Salvage radiotherapy in patients with recurrent esophageal carcinoma

Prognostic Factors for Post-Recurrence Survival in Patients with Thoracic Esophageal Squamous Cell Carcinoma after Curative Resection

Clinical usefulness of18F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy

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Product

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Clinical usefulness of¹⁸F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy