Radiation therapy for paragangliomas of the temporal bone

Abstract

Treatment of paragangliomas of the temporal bone (glomus jugulare and glomus tympanicum tumors) is controversial, with both surgery and radiation therapy having their advocates. This paper discusses the experience at the University of Arizona Health Sciences Center in treating 10 cases of this uncommon tumor between 1971 and 1988. Seven of 10 cases were initially treated using irradiation and achieved complete tumor control for a mean of 67 months (range = 23-107 months). Two patients, one treated surgically and the other by embolization, had recurrences and were salvaged by radiation, and neither has recurred. The final patient is disease-free 9 months after embolization and surgery. There have been no serious sequelae of treatment. We conclude that moderate-dose irradiation can safely control most temporal bone paragangliomas.

Tratamento radioterápico dos tumores glômicos do osso temporal

“…Mean follow up considered as appropriate was more than 11 years to determine a definitive response to the treatment, although it is known that glomus tumors have slow growth rate and some reports mention a recurrence of tumors even after twenty years 9 . Symptoms and findings of physical and additional examinations were not different from those reported in the literature 14,15 , with a long interval between the onset of symptoms and diagnosis 14 . None of the patients obtained improvement in symptoms such as hearing loss, tinnitus or cranial nerve dysfunction after radiotherapy, as found in other series 13,22 .…”

Definitive radiotherapy in the management of paragangliomas arising in the head and neck: A 35‐year experience

“…The likelihood of cure is high and there seems to be no significant difference among the treatment modalities in terms of tumor control (Tables 5 15-17 (Table 7 2,7-9,11-14,20,22,26,26-30,50,59 and Table 8 10, 16,17,40,[45][46][47][48][49][50]53,72,73 ). The probability of tumor control with radiation does not appear to be a function of tumor size, at least when treated to the recommended dose of 45 Gy.…”

“…[16][17][18]23 Malignant paragangliomas are usually diagnosed on the basis of metastatic adenopathy in the neck or distant metastases. The latter group of patients are potentially curable with suitable treatment to the primary site and neck, although the appropriate dose has not FIGURE 2.…”

Fractioned Stereotactic Radiosurgery in Patients with Paraganglioma

“…Fraksiyone eksternal radyoterapi daha çok nüks ya da rezüdü tümör varlığında, bazen de opere edilemeyen hastalarda primer tedavi modalitesi olarak kullanılmaktadır (8). Tümör kontrol oranları %74-97 arasında değişmektedir (8)(9)(10)(11).…”

“…Tümör kontrol oranları %74-97 arasında değişmektedir (8)(9)(10)(11). Definitif RT de kür tanımı, tümörün progrese olmasını engellemektir.…”