Radiation Therapy For Exudative Age-Related Macular Degeneration

Zhou²,

Li³

et al. 1999

Ischemic retinopathy and age-related macular degeneration are the leading ocular diseases that cause blindness. The etiology of these diseases is due in part to the reduction of blood flow in the retina and/or choroid. Crocin analogs isolated from Crocus sativus L. were found to significantly increase the blood flow in the retina and choroid and to facilitate retinal function recovery. Increased blood flow due to vasodilation presumably improves oxygenation and nutrient supply of retinal structures. These results indicated that crocin analogs could be used to treat ischemic retinopathy and/or age-related macular degeneration. It was noted that disaccharide analogs of crocin, such as crocin-1 and crocin-2, were less potent than monosaccharide analogs of crocin, such as crocin-3 and crocin-4, constituting an interesting structure-activity relationship.

Section: Discussionmentioning

confidence: 99%

“…Ischémie retinopathy and age-related macular degeneration (AMD) are leading ocular diseases to cause blindness, yet no effective drag is presently available for their treatment (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Effects of Crocin Analogs on Ocular Blood Flow and Retinal Function

Zhou²,

Li³

et al. 1999

“…Fovea is an avascular tissue which contains only the photocells for sharp image detection during the daytime. It has been reported that age-related macular degeneration (AMD) is closely related to the choroidal vascular abnormality and/or deficiency (6)(7)(8)(9). Therefore, drags such as N-nitropyrazole analogs could be useful for the treatment of AMD as they can increase the choroidal blood flow specifically to facilitate the retinal functions after ischémie insults.…”

Section: Discussionmentioning

confidence: 99%

“…It is exciting to note that N-nitropyrazole analogs can facilitate retinal function recovery after ischémie insult through the increase of choroidal blood flow. Thus, it is possible that these agents could be used for the treatment ofAMD which is pharmacologically untreatable at the present time (6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

“…However, it has been noted that the ultimate goal of lowering IOP is to improve the retinal and choroidal blood flow and to facilitate the nutrient (oxygen and glucose in particular) supply to the retina. Since these actions can also be beneficial to ischémie retinopathy and age-related macular degeneration (AMD) (6)(7)(8)(9), these agents could have wider clinical applicability to treat not only glaucoma and ocular hypertension but ischémie retinopathy and AMD as well. …”

Section: Introductionmentioning

confidence: 99%

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Effects of Some N-Nitropyrazole Derivatives on Ocular Blood Flow and Retinal Function Recovery After Ischemic Insult

Zhou²,

Varma³

et al. 1999

Ocular blood flow and retinal function were determined in this study with colored microspheres and b-wave amplitude of electroretinography, respectively. It was found that N-nitropyrazole analogs can facilitate the retinal function recovery efficiently after ischemic insult primarily through increase of choroidal blood flow specifically. Since age-related macular degeneration (AMD) is caused mainly by the choroidal vascular abnormality and/or insufficiency, these N-nitropyrazole analogs are of potential use in the treatment of AMD.

Effects of N-Nitropyrazoles on Ocular Blood Flow of Rabbits and Retinal Function Recovery of Rat Eyes after Ischemic Insults

Wang²,

Chiou³

et al. 2001

Twelve compounds of N-nitropyrazoles were studied for their effects on ocular blood flow in rabbits and retinal function recovery in rat eyes after ischemic insults. Of the twelve N-nitropyrazoles examined, nine increased choroidal blood flow while five increased retinal blood flow significantly. On the other hand, all twelve compounds increased blood flow in iris and ciliary muscle without exception. As for retinal function recovery after ischemic insult in rat eyes, eight out of the twelve compounds showed more significant facilitation than the control. The structure activity relationship of the N-nitropyrazoles to increase ocular blood flow and to facilitate retinal function recovery after ischemic insults were discussed.