Radiation Therapy for Cancer of the Piriform Sinus

Ij, van Mierlo; Pc, Levendag; Wm, Eijkenboom; Pp, Jansen; Ca, Meeuwis; Pj, van Assendelft; Wl, van Putten; Nowak, Piotr

doi:10.1097/00000421-199512000-00010

Cited by 9 publications

(3 citation statements)

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“…[61] The observed loco regional relapse-free survival and overall survival at 5 years for patients with stage I and II disease treated by radiotherapy alone was 60% and 40%, respectively.…”

Section: Million and Cassisimentioning

confidence: 96%

Early stage squamous cell carcinoma of the pyriform sinus: A review of treatment options

Krstevska

2012

Indian J Cancer

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The purpose of this review of the literature was to present treatment options for early stage pyriform sinus cancer. Squamous cell carcinoma of the pyriform sinus, as the most frequent cancer arising from the hypopharynx, is rarely diagnosed in its early stage. Based on evidence from retrospective studies, conservation surgery and definitive radiotherapy are considered the available treatment modalities for patients presenting with stage T1 and T2 pyriform sinus carcinomas without clinical evidence of neck lymph node metastases, offering similar results with respect to disease control and functional organ preservation. Also, the high risk of occult metastatic nodal disease even in the earliest stage of pyriform sinus cancer entails elective neck dissection or elective neck irradiation to be considered mandatory. However, for patients with early stage pyriform sinus cancer, no level 1 study exists in which conservation surgery is compared with radiotherapy alone for the evaluation of local control or survival. Randomized multicenter controlled trials evaluating efficacy of conservation surgery and definitive radiotherapy, and correctly interpreting functional outcome for each of the treatment procedures examined are necessary to obtain sufficient evidence to influence the decision in the choice of the most effective treatment for early pyriform sinus cancer.

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“…[61] The observed loco regional relapse-free survival and overall survival at 5 years for patients with stage I and II disease treated by radiotherapy alone was 60% and 40%, respectively.…”

Section: Million and Cassisimentioning

confidence: 96%

Early stage squamous cell carcinoma of the pyriform sinus: A review of treatment options

Krstevska

2012

Indian J Cancer

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“…Nakamura et al (Nakamura et al, 2006) reported 5-year local control rates of 85% and 65% for T1 and T2 hypopharyngeal lesions. The observed overall survival at 5 years for stage I and II hypopharyngeal cancer from all sites treated by radiotherapy alone ranged between was 40% and 78% (Pingree et al, 1987;Van Mierlo et al, 1995). In summary, primary conventionally fractionated radiotherapy for T1-2 hypopharyngeal cancers results in a 2year local control rate of 89-100% for T1 tumours and 60-70% for T2 tumours (Fein et al, 1993;Garden et al, 1996;Van Mierlo et al, 1995).…”

Section: Radiotherapymentioning

confidence: 99%

“…The observed overall survival at 5 years for stage I and II hypopharyngeal cancer from all sites treated by radiotherapy alone ranged between was 40% and 78% (Pingree et al, 1987;Van Mierlo et al, 1995). In summary, primary conventionally fractionated radiotherapy for T1-2 hypopharyngeal cancers results in a 2year local control rate of 89-100% for T1 tumours and 60-70% for T2 tumours (Fein et al, 1993;Garden et al, 1996;Van Mierlo et al, 1995). In order to improve local control rates in patients with early hypopharyngeal lesions treated with definitive radiotherapy, altered fractionation regimens were also explored by several authors.…”

Section: Radiotherapymentioning

confidence: 99%

Hypopharyngeal Cancer

Krstevska¹

2012

Head and Neck Cancer

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Primary radiotherapy for squamous cell carcinoma of the pyriform sinus

Mendenhall

Amdur

Morris

et al. 2015

Eur Arch Otorhinolaryngol

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The objective of this study is to report the long-term outcomes of primary radiotherapy (RT) for patients with T1-T2 squamous cell carcinomas (SCC) of the pyriform sinus. Between November 1964 and March 2008, 135 patients with T1-T2 pyriform sinus SCC were treated with primary RT at the University of Florida. Adjuvant chemotherapy was employed in 21 patients (16 %) and 62 patients (46 %) underwent a planned neck dissection. Median follow-up was 3.5 years (range 0.2-24.7 years); median follow-up on living patients was 8.3 years (range 3.8-24.0 years). The 5-year outcomes were as follows: local control, 85 %; regional control, 81 %; local-regional control, 71 %; distant metastasis-free survival, 76 %; cause-specific survival, 62 %; and overall survival, 38 %. The 5-year local control rate was 88 % for T1 cancers and 84 % for those with T2 SCCs (p = 0.5429). Sixteen patients (12 %) experienced severe late complications. Primary RT results in a high probability of cure with a relatively modest risk of severe late complications for patients with T1-T2 SCCs of the pyriform sinus.

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Radiation Therapy for Cancer of the Piriform Sinus

Cited by 9 publications

References 0 publications

Early stage squamous cell carcinoma of the pyriform sinus: A review of treatment options

Early stage squamous cell carcinoma of the pyriform sinus: A review of treatment options

Hypopharyngeal Cancer

Primary radiotherapy for squamous cell carcinoma of the pyriform sinus

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