Radiation Therapy for Aneurysmal Bone Cysts

Zhu, Simeng; Hitchcock, Kathryn; Mendenhall, William M.

doi:10.1097/coc.0000000000000208

Cited by 29 publications

(25 citation statements)

References 23 publications

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“…In a 2015 case series of 12 patients treated with radiotherapy for ABC, Zhu et al reported no recurrence and no complications at final follow-up [26]. Feigenberg et al reported that radiotherapy administered with 26-30 Gy with techniques to minimize scatter was effective and minimally toxic in the treatment of inoperable or recurrent ABC lesions [21].…”

Section: Radiotherapymentioning

confidence: 99%

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Current management of aneurysmal bone cysts

Park

Yang

Sheppard

et al. 2016

Curr Rev Musculoskelet Med

168

259

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Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as Bfluid-fluid levels,^although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Currently, the standard of care and most widely employed treatment is intralesional curettage. However, tumor recurrence with curettage alone is common and has driven some to propose a multitude of adjuvants with varying efficacy and risk profiles. Historically, therapies such as en bloc resection or radiation therapy were utilized as an alternative to decrease the recurrence rate, but these therapies imposed high morbidity. As a result, modern techniques now seek to simultaneously reduce morbidity and recurrence, the pursuit of which has produced preliminary study into minimally invasive percutaneous treatments and medical management.

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Section: Radiotherapymentioning

confidence: 99%

“…Adjuvant radiation therapy is associated with excellent control of ABCs, ranging from 83 to 100 % local control [22,24,26,29,45]. However, complications from radiotherapy include chronic effects that can impair function and secondary malignancies, which have prevented its adoption into widespread practice.…”

Section: Adjuvant Radiotherapymentioning

confidence: 99%

Current management of aneurysmal bone cysts

Park

Yang

Sheppard

et al. 2016

Curr Rev Musculoskelet Med

168

259

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“…They reviewed the medical records of 12 patients who received RT at the mean dose of 30.15 Gy and followed them at least 3 years. No patient showed RT complications or recurrence [13].…”

Section: Discussionmentioning

confidence: 88%

“…In 2006 Kumar et al [12] reported a case of recurrent ABC on temporal bone, which were treated with 31.5 Gy in 18 fractions and found reasonable outcome [12]. Zhu et al [13] evaluated the long-term effectiveness of RT as an adjuvant or alternative treatment for ABC. They reviewed the medical records of 12 patients who received RT at the mean dose of 30.15 Gy and followed them at least 3 years.…”

Section: Discussionmentioning

confidence: 99%

Treatment of an Uncommon Case of Recurrent Cervical Spine Aneurismal Bone Cyst, Using Radiotherapy: A Case Report

Feli¹

2016

JCPCR

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“…Treatment commonly involves curettage or resection [2][3][4][5]. However, other minimally invasive strategies have been previously described, such as radiation therapy, sclerotherapy, embolization, and injection of a variety of enhancer ossification agents [6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

Oliveira¹,

Meohas²,

Carvalho³

et al. 2017

J Orthop Oncol

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Aneurysmal bone cyst is a rare benign bone tumor usually treated by surgery, which may in turn result in poor functional outcome and recurrence. This study aims to report a series of cases of primary ABC treated with a single dose of calcitonin and methylprednisolone injection. Six patients treated with a single-dose combination of calcitonin (200 UI) and methylprednisolone (120 mg) at a single institution from January 2011 to December 2013 were clinically and radiologically evaluated. After the follow-up period, all patients presented cyst healing. The mean time to healing was 2.8 months. The final mean overall functional score rating was 89.0%. We conclude that intralesional calcitonin and methylprednisolone injection results in aneurysmal bone cyst healing with good functional outcomes and thus can be an effective treatment method.

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Radiation Therapy for Aneurysmal Bone Cysts

Abstract: RT continues to result in an excellent prognosis for patients with ABC who receive either RT alone or adjuvant RT after surgery.

Cited by 29 publications

References 23 publications

Current management of aneurysmal bone cysts

Current management of aneurysmal bone cysts

Treatment of an Uncommon Case of Recurrent Cervical Spine Aneurismal Bone Cyst, Using Radiotherapy: A Case Report

Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

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