Radiation Therapy Decision and Field Design after Neoadjuvant Chemotherapy in Breast Cancer: A Review of Neoadjuvant Approach

Abstract

NAC was compared with the same chemotherapy given postoperatively in plenty of randomized trials [12][13][14][15][16]. Accurate interpretation of these data is hardly available because: firstly, frequency of breast-conserving surgery differed between groups and in some trials [17,18] some of the good responders even did not receive surgery. Second drawback is substantial downstaging bias caused by analysis of postsurgical characteristics data in