Radiation Therapy Across Pediatric Hodgkin Lymphoma Research Group Protocols: A Report From the Staging, Evaluation, and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) Group

Abstract

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A Nomogram for Predicting Cancer-Specific Survival of Hodgkin lymphoma in Children and Young Adulthood: an Observational Study using SEER Population-based Data

“…On the contrary, patients who underwent radiation therapy had a higher survival rate than those who did not underwent radiation therapy; this is consistent with the results of a previous study [29]. However, previous study results show that event-free survival (EFS) rates favor patients receiving radiotherapy by up to 10% [30,31]. This may be because all major children and several adult in HL research groups have followed a response-based treatment adaptation and toxicity-saving model over the past thirty years by reducing or eliminating RT.…”

Children's Oncology Group's 2023 blueprint for research: Hodgkin lymphoma

“…Stages IA and IIA without bulk, and IVB have been consistently classified as low and high risk, respectively; all other stages have been classified in more than one risk category dependent on the pediatric trial. The International Staging Evaluation and Response Criteria Harmonization (SEARCH) initiative is working to standardize criteria for baseline disease involvement and for response in pediatric cHL 7,8 . Pediatric‐specific HL guidelines from the National Comprehensive Cancer Network update approaches in terms of stage and risk 9 …”

“…The risk of RT‐related morbidity on pediatric HL survivors has been reduced with a comprehensive approach facilitated by FDG‐PET: irradiating fewer patients in frontline treatment using response‐adapted approaches; evolution from involved‐field to involved‐site, lesion‐based RT with smaller tailored radiation fields, and integrating highly conformal radiotherapy techniques 8,54 (Table 4). A significant reduction in normal tissue dose to breast, heart, and thyroid has been demonstrated with these changes 55 .…”

“…The International Staging Evaluation and Response Criteria Harmonization (SEARCH) initiative is working to standardize criteria for baseline disease involvement and for response in pediatric cHL. 7,8 Pediatric-specific HL guidelines from the National Compre-hensive Cancer Network update approaches in terms of stage and risk. 9…”