Radiation Technologies in Medicine: The Role of Secondary Particles in Forming Doses

Gantsovsky, P. P.; Zheltonozhskaya, M. V.; Komarov, A.; Lykova, E. N.; Tsovyanov, A. G.; Chernyaev, A. P.; Смирнов, Ф.; Zinchenko, Yury P.; Kovyazina, M.; Shilko, R.

doi:10.3103/s1062873820110106

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…The error value around the peak energy was less than The disagreement between the calculated and measured data was less than 17% with a standard deviation of 10% in the energy range of 32 keV to 3.16 MeV. The mean value of photoneutron energy was < E n >= 0.94 ± 0.12 MeVm, in agreement with the measured mean energy reported in [26], which was < E n Measured >= 0.83 ± 0.02 MeV.…”

Section: Resultssupporting

confidence: 82%

“…Accounting for all mentioned factors can make it possible to more accurately determine the additional dose from photoneutrons when planning radiation treatment. As shown in our previous study [26], performed by us earlier, the additional dose can exceed 2 Sv across thirty treatment procedures.…”

Section: Discussionmentioning

confidence: 50%

“…The photoneutron spectrum detected in the tantalum plate is shown in Figure 5. The obtained data were divided into energy intervals similarly to [26]. The measurement error for the maximum value was 7%.…”

Section: Resultsmentioning

confidence: 99%

“…The geometry from the experiment described previously in [26] and the model described above were used for simulation of the photoneutron spectrum (Figure 1). The photon beam was directed vertically down.…”

Section: Methodsmentioning

confidence: 99%

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GEANT4 Simulation of Photoneutron Spectrum from Medical Linear Accelerator

Chernyaev,

Belikhin,

Lykova

et al. 2023

QuBS

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Photons with energy totaling more than 10 MeV provide efficient treatment for deeply seated tumors but interact with the nuclei of high-Z materials constituting a head of the linac. These interactions result in photoneutrons that deliver an additional out-of-field dose to the patient, which increases the risk of radiation-induced cancer. Monte Carlo simulation is an accurate strategy for estimating the effective photoneutron dose for a patient. In the current study, the possibility of using GEANT4 to calculate the photoneutron spectrum from the medical linac was investigated. The free-in-air photoneutron spectrum from a head of the linac was simulated using the NeutronHP experimental package. Validation of the simulated model was carried out based on a comparison of simulated and measured percentage depth–dose curves from photons in the water phantom. The obtained photoneutron spectrum was compared with the previously measured spectrum at the Varian Thilogy linac. GEANT4 may improve the accuracy of calculations of the effective dose based on photoneutrons. However, the simulated model should be improved and optimized. In the future, this model may constitute a physical basis for the prediction of the risk of radiation-induced cancer at our clinical center.

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Section: Resultssupporting

confidence: 82%

Section: Discussionmentioning

confidence: 50%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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GEANT4 Simulation of Photoneutron Spectrum from Medical Linear Accelerator

Chernyaev,

Belikhin,

Lykova

et al. 2023

QuBS

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Study of Light Nuclei Activation in Human Blood During High-Energy Linear Accelerator (Linac) Radiation Therapy

Zheltonozhskaya,

Remizov,

Lenivkin

et al. 2023

Moscow Univ. Phys.

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Study of light element activation in human blood during 20 MeV linac operating

Zheltonozhskaya,

Remizov,

Lenivkin

et al. 2023

VMU

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A series of experiments have been performed to study the activation of chemical macronutrients in human venous blood throughout radiation treatment with the 20 MeV linac. Some elements in the human blood can be activated as positron-emitting radionuclides by (𝛾, n)-reaction. We calculated the 11C, 13N, 15O, 30P, 34𝑚Cl, and 38K activities in irradiated human venous blood samples for the first time. As a result, we concluded that the main contribution to the dose from positron-emitting nuclides activated in human blood provides three nuclides: 15O, 34𝑚Cl, and 38K.

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Radiation Technologies in Medicine: The Role of Secondary Particles in Forming Doses

Cited by 3 publications

References 17 publications

GEANT4 Simulation of Photoneutron Spectrum from Medical Linear Accelerator

GEANT4 Simulation of Photoneutron Spectrum from Medical Linear Accelerator

Study of Light Nuclei Activation in Human Blood During High-Energy Linear Accelerator (Linac) Radiation Therapy

Study of light element activation in human blood during 20 MeV linac operating

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