Recently the replacing of the petrochemical origin polymers with biopolymers and biocomposites which are environmental biodegradable polymers became a growing interest. The use of gamma radiation for synthesis and produce further modification of the biopolymers and biocomposites found to be suitable for biomedical application due to none using of toxic additives. Moreover, the radiation technique is the combining of preparation and sterilization in a one technological step thus, reducing time of the production and lower the costs. The use of gamma radiation technique in biomedical application is growing rapidly in controlled drug delivery, injectable materials, wound dressing, tissue engineering, immobilized enzymes and biosensors.