Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release

Abstract

Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4-7.5 was investigated. It is found that the swelling behavior of Poly (BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates.

Radiation-induced grafting of acrylamide and methacrylic acid individually onto carboxymethyl cellulose for removal of hazardous water pollutants

“…For kinetic analysis of the results, Fick's law was applied which was described previously. [22] The swelling/diffusion kinetic parameters, as diffusion coefficients (D), swelling rate constant (k), diffusion constant (n), and maximum equilibrium swelling ratio, were calculated using the dynamic swelling ratio values for the prepared hydrogels by the following equation:…”

“…The diffusion of water into the hydrogel was classified into three different types based on the relative rates of diffusion and polymer relaxation as mentioned in the experimental part. [22] Figure 3(a)-(d) shows the relation between time and fraction of swelling due to water uptake. The diffusion constant (n) for the different compositions of Poly(CMC/AAm) and Poly(CMC/MAAc) hydrogels (1/20 wt%) is obtained from Figure 3 …”

Synthesis and Antimicrobial Properties of Highly Cross-Linked pH-Sensitive Hydrogels through Gamma Radiation

“…Hydrogels were synthesized by a direct gamma-radiation method [ 29 , 30 ]. This method involves a simultaneous cross-linked polymerization of AAc and agar (one step), generating free radicals and obtaining the poly(Agar- co -AAc) hydrogels.…”

Superabsorbent Hydrogel from Cassava Waste Pulp – Acrylamide – Acrylic Acid to Increase Water Holding Capacity in Sandy Soils

“…The variable n represents the swelling exponent, which serves as an indicator of the diffusion mechanism within the hydrogels, determined by computing the slope of the curve representing this relationship. The variables Mt and M∞ represent the hydrogel mass at time t immersion (in grammes) and the hydrogel mass at equilibrium (in grammes), respectively [10]. Equation ( 4) is used for implementing Fick's Law to calculate the diffusion coefficient (D).…”

“…This value represents the velocity at which water and urea molecules traverse through the hydrogels material. The rate at which the solution is released into the polymer chain is directly related to the diffusion coefficient [10]. This value is closely correlated with the equilibrium degree of swelling.…”