Radiation suppresses neointimal hyperplasia through affecting proliferation and apoptosis of vascular smooth muscle cells

Yuan, Liqin; Shu, Chang; Zhou, Xiao Yan; Li, Jiehua; Wang, Lunchang; Li, Xin; Xiong, Xiang; Li, Lun

doi:10.5301/jva.5000804

Cited by 4 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, controversial findings were reported about the impact of radiation on the angiogenesis and metastasis. Different studies indicated that damaged blood vessels may promote angiogenesis, migration of cancer cells, metastasis, and exacerbate the prognosis outcome ( Girinsky, 2000 ; Quail and Joyce, 2013 ; Chaurasia et al, 2016 ; Hu et al, 2016 ; Manier et al, 2016 ; Viallard and Larrivee, 2017 ; Yadav et al, 2018 ; Yuan et al, 2018 ; Schulz et al, 2019 ). Despite this negative side effects in endothelium, efficient cancer elimination and better overall survival were observed during radiation treatment in many different cancers ( Chaurasia et al, 2016 ; Hu et al, 2016 ; Yuan et al, 2018 ), suggesting that the balance towards complete cancer elimination is under control of specific component(s) in TME.…”

Section: Radiation Therapy Effects In Tumor Vasculaturementioning

confidence: 99%

“…A unique tumor-associated vasculature is activated through a variety of mechanisms, including an increased level of reactive oxygen spices (ROS) and activation of mechanistic target of rapamycin (mTOR) pathway ( Quail and Joyce, 2013 ; Chaurasia et al, 2016 ; Hu et al, 2016 ; Manier et al, 2016 ; Schulz et al, 2019 ). Therefore, radiation therapy was found to stimulate not only the autophagy/apoptosis in cancer cells, but also proliferation of blood vessels near the treated tumor, increasing the degree of blood supply to tumor cells and promoting tumor metastasis ( Girinsky, 2000 ; Yadav et al, 2018 ; Yuan et al, 2018 ).…”

Section: Radiation Therapy Effects In Tumor Vasculaturementioning

confidence: 99%

See 1 more Smart Citation

Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers

Zhao,

Mo,

Neganova

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Successful clinical methods for tumor elimination include a combination of surgical resection, radiotherapy, and chemotherapy. Radiotherapy is one of the crucial components of the cancer treatment regimens which allow to extend patient life expectancy. Current cutting-edge radiotherapy research is focused on the identification of methods that should increase cancer cell sensitivity to radiation and activate anti-cancer immunity mechanisms. Radiation treatment activates various cells of the tumor microenvironment (TME) and impacts tumor growth, angiogenesis, and anti-cancer immunity. Radiotherapy was shown to regulate signaling and anti-cancer functions of various TME immune and vasculature cell components, including tumor-associated macrophages, dendritic cells, endothelial cells, cancer-associated fibroblasts (CAFs), natural killers, and other T cell subsets. Dual effects of radiation, including metastasis-promoting effects and activation of oxidative stress, have been detected, suggesting that radiotherapy triggers heterogeneous targets. In this review, we critically discuss the activation of TME and angiogenesis during radiotherapy which is used to strengthen the effects of novel immunotherapy. Intracellular, genetic, and epigenetic mechanisms of signaling and clinical manipulations of immune responses and oxidative stress by radiotherapy are accented. Current findings indicate that radiotherapy should be considered as a supporting instrument for immunotherapy to limit the cancer-promoting effects of TME. To increase cancer-free survival rates, it is recommended to combine personalized radiation therapy methods with TME-targeting drugs, including immune checkpoint inhibitors.

show abstract