Radiation sterilisation of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles

Maksimenko, Olga; Pavlov, E.P.; Toushov, E.; Molin, A. A.; Stukalov, Yu. V.; Prudskova, T. N.; Feldman, Vladimir I.; Kreuter, Jörg; Gelperina, Svetlana

doi:10.1016/j.ijpharm.2008.01.010

Cited by 43 publications

(14 citation statements)

References 18 publications

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“…27 These solvents, as well as their mixtures in different proportions, were evaluated through visual observation with regard to their ability of efficiently disrupt nanoparticles. The best solvent composition was found to be MeOH:ACN (8:2, v/v); however, a previous addition of HCl solution (0.1 M, 1.0 mL) (pH 1.2) was necessary to ensure complete solubilization of ACV.…”

Section: Resultsmentioning

confidence: 99%

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles

et al. 2012

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Recebido em 28/2/11; aceito em 13/6/11; publicado na web em 8/8/11A derivative spectrophotometric method was validated for quantification of acyclovir in poly (n-butylcyanoacrylate) (PBCA) nanoparticles. Specificity, linearity, precision, accuracy, recovery, detection (LOD) and quantification (LOQ) limits were established for method validation. First-derivative at 295.2 nm eliminated interferences from nanoparticle ingredients and presented linearity for acyclovir concentrations ranging from 1.25 to 40.0 µg/mL (r = 0.9999). Precision and accuracy data demonstrated good reproducibility. Recovery ranged from 99.3 to 101.2. LOD was 0.08 µg/mL and LOQ, 0.25 µg/mL. Thus, the proposed method proved to be easy, low cost, and accurate, and therefore, an useful alternative to quantify acyclovir in nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles

et al. 2012

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“…The formulation showed excellent stability to irradiation. The drug was stable to radiolysis while the molecular weights of the PBCA polymer remained nearly unchanged (232).…”

Section: Sterilizationmentioning

confidence: 99%

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.

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“…Irradiation of mannitol produced free radicals, which are stable enough under ambient conditions. In particular, it was shown that irradiation of some medical compositions containing mannitol to typical sterilization doses (10 -25 kGy) led to accumulation of stable radicals readily detectable by EPR spectroscopy [1]. These radicals may serve as markers of irradiation of the corresponding specimens.…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced radicals in different polymorphic modifications of d -mannitol: Structure, conformations and dosimetric implications

Sosulin

Shiryaeva

Feldman

2015

Radiation Physics and Chemistry

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Radiation sterilisation of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles

Cited by 43 publications

References 18 publications

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Radiation-induced radicals in different polymorphic modifications of d -mannitol: Structure, conformations and dosimetric implications

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