Radiation Retinopathy as an Experimental Model for Ischemic Proliferative Retinopathy and Rubeosis Iridis

Irvine, Alexander R.; Wood, Irmgard

doi:10.1016/s0002-9394(14)74395-8

Cited by 77 publications

(46 citation statements)

References 11 publications

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“…10 As areas of capillary loss become confluent, nerve fiber layer infarctions are seen. Larger vessels are involved later in the course of the disease, and vascular sheathing becomes apparent.…”

Section: Commentmentioning

confidence: 99%

Radiation Retinopathy Following Plaque Radiotherapy for Posterior Uveal Melanoma

Günduz

Shields²,

Shields³

et al. 1999

Arch Ophthalmol

181

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To identify the risk factors that lead to the development of radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Radiation retinopathy is a slowly progressive, occlusive vasculopathy characterized by radiation-induced endothelial damage.Methods: Review of the medical records of patients with posterior uveal melanoma treated with plaque radiotherapy.Results: Of 1300 patients with posterior uveal melanoma treated with plaque radiotherapy from July 1, 1976, through June 30, 1992, radiation retinopathy developed in 560 (43.1%). By using Kaplan-Meier survival estimates, we found that 5% of the patients had nonproliferative radiation retinopathy at 1 year (95% confidence interval [CI], 3%-6%) and 42% at 5 years (95% CI, 38%-45%). The proportion of patients with proliferative retinopathy was 1% at 1 year (95% CI, 0.2%-1.5%) and 8% at 5 years (95% CI, 5%-10%). Multivariate analyses showed that the subset of clinical variables best related

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Section: Commentmentioning

confidence: 99%

Radiation Retinopathy Following Plaque Radiotherapy for Posterior Uveal Melanoma

Günduz

Shields²,

Shields³

et al. 1999

Arch Ophthalmol

181

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“…Nonetheless, endothelial cell proliferation has been shown in BRVO animal models 19,30 and in other vasodegenerative conditions, such as diabetic retinopathy and radiation retinopathy. 31,32 In some instances, basement membrane duplication have been described, [32][33][34] which could have been deposited in sequence by proliferating and dying endothelial cells 35 ; a mechanism that may have contributed to the basement membrane broadening in our CRVO case. Endothelial cell turnover might also be linked to the conversion of nonischemic to ischemic CRVO-the expansion of the nonperused region.…”

Section: Discussionmentioning

confidence: 74%

“…36,37 Persistent basement membrane in vasodegeneration conditions in the retinal vasculature may also have therapeutic implications, as the remaining structures can potentially provide a scaffold for vascular regrowth. 38 Re-endothelialization of acellular basement membranes has been observed numerous times in model systems, 7,32,33,39,40 as well as in patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy

Powner

Sim

Zhu

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Retinal ischemia has been traditionally assessed by fluorescein angiography, visualizing perfused vessels. However, this method does not provide any information about nonperfused vessels, and although it is often assumed that vessels in ischemic areas regress, we know little about how nonperfused retinal vessels change over time. Here, we aim to learn more about the long-term fate of nonperfused vessels in the retinal vasculature.METHODS. Optical coherence tomography (OCT) was used to visualize perfusion as well as structural properties of the retinal vasculature in patients suffering from retinal vascular occlusions. In addition, postmortem tissue from a patient with long standing (6 years) central retinal vein occlusion (CRVO) was investigated, using immunohistochemistry on wholemount retina and paraffin sections to visualize blood vessel components. RESULTS.Comparing OCT angiography with enface OCT images revealed that in ischemic areas of the retina, nonperfused, larger vessels could be detected as hyperreflective structures in enface OCT images. Furthermore, analysis of a postmortem tissue sample from a CRVO patient with a large nonperfused region in the macula, revealed preservation of the basement membrane from all retinal vessels, including nonperfused, acellular vessels of all calibers.CONCLUSIONS. Our data suggests long-term preservation of vascular basement membrane in ischemic retina. This has implications for therapeutic approaches aiming to alleviate retinal ischemia via the regeneration of damaged vessels.

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“…Moreover, experimental ocular irradiation may lead to iris neovasculariza tion and radiation retinopathy, with large nonperfusion areas, but usually fails in in ducing retinal new vessel development [26]. Phenomena other than liberation of angio genic factor from ischemic retina may be involved in iris neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Acidic Fibroblast Growth Factor Distribution in Normal Human Eye and Possible Implications in Ocular Pathogenesis

Baudouin

Fredj-Reygrobellet²,

Caruelle³

et al. 1990

Ophthalmic Res

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Using a rabbit anti-acidic fibroblast growth factor (anti-aFGF) antiserum, we tried to establish a precise mapping of aFGF localization in normal human ocular structures, from samples obtained by autopsies. Cell cultures of retinal pigment epithelium and ciliary pigment epithelium were also established and immunofluorescence studies were performed after 1 month. Corneal and conjunctival epithelia were strongly positive for anti-aFGF antibodies as well as the subcapsular epithelium of the lens. The cortical fibers were weakly reactive and the lens nucleus negative. A strong intracytoplasmic reactivity was observed in the pigmented and nonpigmented epithelial cells of ciliary processes and pars plana, both ex vivo and in vitro. Retina was brightly positive, mostly in the photoreceptor and plexiform layers. The possible involvement of aFGF in normal eye growth and in various ocular diseases was then discussed.

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Radiation Retinopathy as an Experimental Model for Ischemic Proliferative Retinopathy and Rubeosis Iridis

Cited by 77 publications

References 11 publications

Radiation Retinopathy Following Plaque Radiotherapy for Posterior Uveal Melanoma

Radiation Retinopathy Following Plaque Radiotherapy for Posterior Uveal Melanoma

Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy

Acidic Fibroblast Growth Factor Distribution in Normal Human Eye and Possible Implications in Ocular Pathogenesis

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