Radiation Response Genotype and Risk of Differentiated Thyroid Cancer: A Case-Control Analysis

Zhao, Chong; Zheng, Rong; Wei, Qingyi

doi:10.1097/01.mlg.0000163765.88158.86

Cited by 44 publications

(48 citation statements)

References 29 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The product of XRCC3 is a RAD51 paralog necessary for the binding and stabilization of the latter during DNA repair. In our study, the increased risk of rs861539 polymorphism in thyroid cancer is comparable to previous results reporting significant associations with thyroid cancer risk [36-40]. Nevertheless, many studies have found no evident correlation between XRCC3 polymorphisms and thyroid cancer [41, 42].…”

Section: Discussionsupporting

confidence: 88%

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Sarwar¹,

Mahjabeen²,

Bashir³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls. Methods: Genotyping was performed using Allele-specific PCR followed by sequencing. Statistical analysis was performed to analyse gene and haplotype association. Results: After analysis, frequency of mutant genotype/alleles of SNPs (rs1799796, p<0.0001; rs1799794, p<0.0001; rs861539, p<0.001; rs709399, p <0.0001; rs861530, p<0.002) was found significantly higher in thyroid cancer patients compared to controls. Significant associations were found for most of the variant genotypes in SNPs of rs1799794, rs1799796, rs861539, rs861530 and rs709399 in papillary thyroid and follicular cancer patients compared to other histologic subtypes of thyroid carcinoma. Additionally, haplotype analysis revealed that haplotypes, AACGA (p= 0.0005), AGTAA (p= 0.008), GATAA (p= 0.001), GGCAA (p= 0.001) were linked with significant increase in thyroid cancer risk. However, haplotype AGCGG (p= 0.0009) was associated with a significant reduced thyroid cancer risk. Conclusion: Our results suggest that common genetic variants in the XRCC3 gene of DSBR pathway may modulate thyroid cancer risk.

show abstract

Section: Discussionsupporting

confidence: 88%

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Sarwar¹,

Mahjabeen²,

Bashir³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…In addition, assessment of allele frequency distribution revealed a fairly significant involvement of XRCC3 T241M variant allele (T) on individual susceptibility toward DTC (p value: 0.058). The results are similar to earlier reports with regard to differentiated thyroid cancer in Caucasian Portuguese (Bastos et al, 2009) and a non-Hispanic white population (Sturgis et al, 2005). They found XRCC3 variant allele was associated with a twofold increased risk of thyroid cancer.…”

Section: Discussionsupporting

confidence: 91%

Increased Risk of Differentiated Thyroid Carcinoma with Combined Effects of Homologous Recombination Repair Gene Polymorphisms in an Iranian Population

Fayaz

Karimmirza²,

Tanhaei³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Data on the TP53 and XRCC3 polymorphisms associations are quite limited (Hillebrandt et al 1997, Boltze et al 2002, Granja et al 2004, Sturgis et al 2005, Rogounovitch et al 2006. Therefore, in this study, we addressed the relation of SNPs in aforementioned DNA damage response genes to the risk of PTCs of different etiology.…”

Section: Introductionmentioning

confidence: 96%

“…The XRCC3 Thr241Met polymorphism has been controversially associated with different human malignancies (Han et al 2006). Sturgis et al (2005) reported 241Met allele association with the risk of differentiated thyroid cancer.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma

Akulevich¹,

Saenko²,

Rogounovitch³

et al. 2009

Endocrine-Related Cancer

121

View full text Add to dashboard Cite

Papillary thyroid carcinoma (PTC) etiologically occurs as a radiation-induced or sporadic malignancy. Genetic factors contributing to the susceptibility to either form remain unknown. In this retrospective case-control study, we evaluated possible associations between singlenucleotide polymorphisms (SNPs) in the candidate DNA damage response genes (ATM, XRCC1, TP53, XRCC3, MTF1) and risk of radiation-induced and sporadic PTC. A total of 255 PTC cases (123 Chernobyl radiation-induced and 132 sporadic, all in Caucasians) and 596 healthy controls (198 residents of Chernobyl areas and 398 subjects without history of radiation exposure, all Caucasians) were genotyped. The risk of PTC and SNPs interactions with radiation exposure were assessed by logistic regressions. The ATM G5557A and XRCC1 Arg399Gln polymorphisms, regardless of radiation exposure, associated with a decreased risk of PTC according to the multiplicative and dominant models of inheritance (odds ratio (OR)Z0.69, 95% confidence interval (CI) 0.45-0.86 and ORZ0.70, 95% CI 0.59-0.93 respectively). The ATM IVS22-77 TOC and TP53 Arg72Pro SNPs interacted with radiation (PZ0.04 and PZ0.01 respectively). ATM IVS22-77 associated with the increased risk of sporadic PTC (ORZ1.84, 95% CI 1.10-3.24) whereas TP53 Arg72Pro correlated with the higher risk of radiogenic PTC (ORZ1.80, 95% CI 1.06-2.36). In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations, the GG/TC/CG/GC genotype strongly associated with radiation-induced PTC (ORZ2.10, 95% CI 1.17-3.78). The GG/CC/GG/GG genotype displayed a significantly increased risk for sporadic PTC (ORZ3.32, 95% CI 1.57-6.99). The results indicate that polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.

show abstract

Radiation Response Genotype and Risk of Differentiated Thyroid Cancer: A Case-Control Analysis

Abstract: In this case-control analysis, the XRCC3 18067T polymorphism is associated with DTC risk. However, such work needs confirmation in larger studies.

Cited by 44 publications

References 29 publications

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Increased Risk of Differentiated Thyroid Carcinoma with Combined Effects of Homologous Recombination Repair Gene Polymorphisms in an Iranian Population

Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma

Contact Info

Product

Resources

About