Radiation recall dermatitis due to gemcitabine does not suggest the need to discontinue chemotherapy

Lock, Michael; Sinclair, Kevin J.; Welch, Stephen; Younus, Jawaid; Salim, Mohammad

doi:10.3892/ol.2010.195

Cited by 19 publications

(18 citation statements)

References 21 publications

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“…The consensus in available literature indicates discontinuation of the chemotherapeutic agent coupled with steroid or anti‐inflammatory treatment seems to resolve the condition. Many clinicians recommend permanent discontinuation of the causative medication while others suggest re‐challenging the patient with the offending chemotherapeutic agent with some reports of success …”

Section: Discussionmentioning

confidence: 99%

Pectoralis major radiation recall

Hack

Thachil

Karanth

2018

J of Medical Radiation Sci

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Radiation recall is an uncommon phenomenon describing an acute localised inflammatory toxicity affecting tissue previously exposed to radiotherapy. It is precipitated by administration of certain medications, including chemotherapy. We describe a case involving a 50-year-old Aboriginal male smoker from a remote community in Northern Australia who underwent treatment for stage IV non-small cell lung cancer with localised radiotherapy to the primary right upper lung lobe tumour. This was followed by a course of gemcitabine, which was ceased prematurely after four cycles when he presented with radiation recall to his right pectoralis major. Our case description is complemented with a brief review of current literature regarding our case and gemcitabine-related radiation recall. This was in the context of concurrent musculoskeletal strain, an as-yet unreported association with radiation recall. His condition settled with steroid administration and discontinuation of gemcitabine.

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Section: Discussionmentioning

confidence: 99%

Pectoralis major radiation recall

Hack

Thachil

Karanth

2018

J of Medical Radiation Sci

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“…Thus, the decision whether to continue or withdraw offending agents remains controversial [21]. Although steroids are commonly used in the management of radiation recall, the use of ibuprofen with vitamins C and E was in 1 case report [22]. Immediate improvement has been reported with systemic steroids, which were followed by a short tapering regimen.…”

Section: Discussionmentioning

confidence: 99%