Radiation reaction recall following simvastatin therapy: A new observation

Abadir, Rushdy; Liebmann, James

doi:10.1016/s0936-6555(05)80545-x

Cited by 77 publications

(50 citation statements)

References 6 publications

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“…The Oncologist ® without the use of antihistamines or steroids [4,7,14,23]. In our patient, complete resolution occurred within 7 days.…”

Section: Radiation Recall Dermatitis With Cefotetanmentioning

confidence: 72%

“…These include the plant alkaloids, docetaxel [3][4][5], anthracyclines, bleomycin, and alkylating agents including carboplatin [3]. Antiestrogen drugs [6], simvastatin [7], interferon-α2b [8], antituberculous drugs [9], and ultraviolet radiation [10] have also been implicated. While mainly associated with the skin, radiation recall reactions can affect other sites, such as the bowel, esophagus [11], lungs [3], and vaginal mucosa [12].…”

Section: Introductionmentioning

confidence: 99%

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Radiation Recall Dermatitis with Cefotetan: A Case Study

Ayoola

Lee

2006

The Oncologist

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Radiation recall dermatitis (RRD) is an inflammatory skin reaction that occurs in a previously irradiated body part following drug administration. This phenomenon may occur from days to years following exposure to ionizing radiation. The case of a 54-year-old Caucasian woman who was initially treated with external-beam radiation to the right thoracic region following the diagnosis of a poorly differentiated squamous cell carcinoma of the right lung is reported. She received four cycles of consolidated chemotherapy with docetaxel and carboplatin. Four months later, she was admitted to the hospital for acute cholecystitis and was placed on cefotetan. She developed a tender, erythematous rash on the posterior region of her right thorax 48 hours later. The drug was withdrawn, supportive care was instituted, and the patient subsequently improved. RRD should be suspected in patients who develop an erythematous rash in a previously irradiated region. To our knowledge this entity has not been associated with cefotetan previously.

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“…The Oncologist ® without the use of antihistamines or steroids [4,7,14,23]. In our patient, complete resolution occurred within 7 days.…”

Section: Radiation Recall Dermatitis With Cefotetanmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Radiation Recall Dermatitis with Cefotetan: A Case Study

Ayoola

Lee

2006

The Oncologist

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“…The first case described involved the antitumour antibiotic actinomycin D. However, recall reaction also occurs with other classes of chemotherapy agents, including anthracyclines (doxorubicin), alkylating agents (cyclophosphamide), antimetabolites (methotrexate), nucleoside analogs (gemcitabine), and taxanes 13,14 . It has also occurred with other classes of drugs including tamoxifen, simvastatin, and the anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide) [7][8][9]22,23 . Although radiation recall is usually precipitated by drugs, it has also occurred with exposure to ultraviolet light 24 .…”

Section: Discussionmentioning

confidence: 99%

“…However, radiation recall has also been reported with the used of tamoxifen, simvastatin, and anti-tuberculosis medication [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Radiation Recall Dermatitis with Azithromycin

Vujovic

2010

Current Oncology

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Radiation recall is a well-known phenomenon that involves the "recall" of an acute inflammatory reaction in a previously irradiated region after administration of certain drugs. The most common type of radiation recall is radiation recall dermatitis, which involves the reoccurrence of an acute inflammatory skin reaction in previously irradiated skin. Most radiation recall reactions are attributable to chemotherapeutic agents. One previously reported case of radiation recall dermatitis occurred after administration of an antibiotic. The present case report is the second of radiation recall dermatitis involving an antibiotic: azithromycin.

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“…However, it has been reported that it is also observed with tuberculosis drugs, antibiotics, tamoxifen, and simvastatin (60)(61)(62)(63). Radiation "recall phenomenon" is generally seen in skin exposed to radiotherapy, but it has been also found in the lung, gastrointestinal system, muscle, central nervous system, and supraglottic region (64).…”

Section: Radiation "Recall Phenomenon"mentioning

confidence: 99%

Pulmonary Toxicities and Treatment of Radiation Therapy

Argüder¹,

Yıldırım²,

Hasanoğlu³

2015

Eurasian J Pulmonol

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Radiotherapy (RT), used for the treatment of cancers, such as lung cancer, lymphoma, breast cancer, bone marrow transplantation, and esophageal cancer, causes the exposure of lungs to radiation. Since the lungs are very sensitive to ionizing radiation, radiation-induced lung diseases due to radiation therapy are usually common. In this article, lung diseases secondary to RT and the diagnosis and treatment of these diseases were evaluated in light of the literature.Keywords: Cancer, lung, radiotherapy, toxicity INTRODUCTIONThe exposure of normal tissues, besides cancerous tissues, to radiation from the first days of radiotherapy (RT) application has been an important limiting factor. Although the incidence of radiation-induced normal tissue injury has diminished with the development of radiation oncology technology in recent years, it still goes on. In this review, general information about RT is given, and RT-induced toxicity types that develop in the lungs and therapies are explained. GENERAL INFORMATIONRT is used for palliative, curative, adjuvant, and prophylactic purposes in cancer treatment. The aim during radiotherapy application is to reduce or remove tumor load while protecting normal tissue. The injury of normal tissue always poses the main obstacle to RT. In time, strategies, such as dose-volume modulation, image-guided RT applications, involved-field radiotherapy, and the use of lung disease-preventive agents, have been developed to overcome this problem Thoracic RT may be conducted in cases, such as lung cancer, bone marrow transplantation, and esophageal cancer. Lungs are among the most sensitive organs to ionizing radiation, and this sensitivity is one of the most important dose-limiting obstacles of thoracic RT. Temporary sequential inflammatory events are seen in the lung tissue as a response to radiation exposure. Here, individual differences, by affecting the outcome, bring about the occurrence of normal or pathological responses. Radiation-induced lung injury is a progressive process, including inflammation and repair. The development of injury may be prevented and the development of new strategies for treatment may be possible by understanding the underlying mechanisms of the basic molecular damage caused by radiotherapy (1, 2).Today, external RT (EBRT), brachytherapy, intraoperative RT (IORT), stereotactic RT (SRT), three-dimensional conformal RT (3D-CRT), intensity-modulated RT (IMRT), image-guided RT (IGRT), tomotherapy, cyberknife (robotic radiosurgery), boron neutron capture therapy, and hyperthermia are among RT applications. Location of the tumor, its histopathological feature, sensitivity to RT, the patient's undergoing surgical intervention, and his receiving chemotherapy are important for the preference of the appropriate technique (3). 150Radiation has an impact on the alveolocapillary unit of the lung according to the proliferation of cells. Endothelial, epithelial (particularly, type 2 pneumocytes producing surfactant), and reticuloendothelial system cells are more sensi...

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Radiation reaction recall following simvastatin therapy: A new observation

Cited by 77 publications

References 6 publications

Radiation Recall Dermatitis with Cefotetan: A Case Study

Radiation Recall Dermatitis with Cefotetan: A Case Study

Radiation Recall Dermatitis with Azithromycin

Pulmonary Toxicities and Treatment of Radiation Therapy

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