Radiation protocols determine acute graft-versus-host disease incidence after allogeneic bone marrow transplantation in murine models

Schwarte, Sebastian; Bremer, Michael; Fruehauf, Joerg; Sorge, Yanina; Skubich, Susanne; Hoffmann, Matthias

doi:10.1080/09553000701534572

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…CD4 + , CD8 + or T Reg cells) that are transferred with donor bone marrow can affect the severity of the disease (Sprent et al, 1988; Korngold, 1992; Edinger et al, 2003). Second, irradiation dose is proportional to the degree of tissue damage and the subsequent cytokine storm, and thus is directly proportional to aGvHD-related mortality in the mouse (Hill et al, 1997; Schwarte and Hoffmann, 2005; Schwarte et al, 2007). In addition, the dose of irradiation that is myeloablative varies by mouse strain: inbred strains are generally more susceptible to radiation than their F1 progeny, and different strains show susceptibility differences (e.g.…”

Section: Mouse Models Of Agvhdmentioning

confidence: 99%

Mouse models of graft-versus-host disease: advances and limitations

Schroeder

DiPersio

2011

Disease Models &Amp; Mechanisms

244

237

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The limiting factor for successful hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kinetics with which GvHD develops distinguishes acute from chronic GvHD, and it is clear from studies of mouse models of GvHD (and studies of human HSCT) that the pathophysiology of these two forms is also distinct. Mouse models also further the basic understanding of the immunological responses involved in GvHD pathology, such as antigen recognition and presentation, the involvement of the thymus and immune reconstitution after transplantation. In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.

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Section: Mouse Models Of Agvhdmentioning

confidence: 99%

Mouse models of graft-versus-host disease: advances and limitations

Schroeder

DiPersio

2011

Disease Models &Amp; Mechanisms

244

237

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“…Radiation impact on developing brain, bone, eyes and teeth as well as on heart, lung, kidney, may complicate interpretation of disease or death related to rejection, GVHD, or other research endpoints. [186][187][188][189][190][191][192][193][194][195] Ultraviolet (UV) radiation effects on local skin immunity are especially relevant to research on photocarcinogenesis or inflammatory skin conditions. [196][197][198] Effects vary with dose, duration of exposure and wavelength composition.…”

Section: Cpg Oligodeoxynucleotidesmentioning

confidence: 99%

Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research

Radælli

Santagostino²,

Sellers

et al. 2018

ILAR Journal

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In 1989 ILAR published a list and description of immunodeficient rodents used in research. Since then, advances in understanding of molecular mechanisms; recognition of genetic, epigenetic microbial, and other influences on immunity; and capabilities in manipulating genomes and microbiomes have increased options and opportunities for selecting mice and designing studies to answer important mechanistic and therapeutic questions. Despite numerous scientific breakthroughs that have benefitted from research in mice, there is debate about the relevance and predictive or translational value of research in mice. Reproducibility of results obtained from mice and other research models also is a well-publicized concern. This review summarizes resources to inform the selection and use of immune relevant mouse strains and stocks, aiming to improve the utility, validity, and reproducibility of research in mice. Immune sufficient genetic variations, immune relevant spontaneous mutations, immunodeficient and autoimmune phenotypes, and selected induced conditions are emphasized.

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“…Furthermore, these systems are suitable for whole body irradiation of small animals which is of great importance to assure sufficient immunosuppression for tumour or bone marrow transplantations. As the technical demands are typically low, such simple devices as well as X-ray systems (industrial or clinical) or even clinical linear accelerators may be utilised [32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Irradiation Device Propertiesmentioning

confidence: 99%

Pre-clinical research in small animals using radiotherapy technology – a bidirectional translational approach

Tillner

Thute

Bütof

et al. 2014

Zeitschrift für Medizinische Physik

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Radiation protocols determine acute graft-versus-host disease incidence after allogeneic bone marrow transplantation in murine models

Abstract: Experimental TBI in murine models may induce different immunological responses, depending on total energy, total single dose and dose rate. GvHD might also be induced by TBI with low dose rates.

Cited by 9 publications

References 40 publications

Mouse models of graft-versus-host disease: advances and limitations

Mouse models of graft-versus-host disease: advances and limitations

Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research

Pre-clinical research in small animals using radiotherapy technology – a bidirectional translational approach

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