Radiation proctopathy in the treatment of prostate cancer

Garg, Amit; Yuan, Wei; McGary, John E.; Grant, Walter H.; Butler, E. Brian; Teh, Bin S.

doi:10.1016/j.ijrobp.2006.07.1386

Cited by 59 publications

(48 citation statements)

References 88 publications

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“…Therapeutic options described in the literature for rectal bleeding due to chronic actinic proctitis are diverse and have to be selected based on symptoms (RTOG/EORTC of acute and chronic toxicity scales) (6)(7)(8). In patients with grade-1 proctitis enemas with steroids and 5-ASA derivatives can be used.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of argon plasma coagulation in the treatment of chronic actinic proctitis

Tormo

Wikman-Jorgensen

Castillo

et al. 2009

Rev. esp. enferm. dig.

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Introduction: there are two kinds of actinic proctitis -one is acute and self-limited, and lasts about 3 months; the other is chronic and develops months to years after radiation therapy. The incidence of chronic actinic proctitis is about 5-20% of radiated prostate tumors.Objective: to evaluate the effectiveness of argon plasma coagulation in the treatment of chronic actinic proctitis.Material and method: a retrospective search of patients with the diagnosis of actinic proctitis. The number of argon plasma coagulation therapies needed to achieve the symptom resolution was analyzed.Results: we found 22 patients with a diagnosis of actinic proctitis. Nineteen were males (86.7%) and three (13.6%) were females. Nineteen patients (86.4%) had a diagnosis of prostate adenocarcinoma, one had a diagnosis of squamous-cell cervix carcinoma (4.5%), and two had a diagnosis of endometrial carcinoma (9.1%). The mean number of coagulation sessions needed for symptom resolution was 2.58 (absolute range 1-7) with a median of 2 sessions.Conclusion: multiple treatments are described in the literature. None of them have shown promising results. Our results suggest that argon plasma coagulation is effective in the treatment of this condition, and achieves a rapid and sustained response with few sessions and a good safety profile.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of argon plasma coagulation in the treatment of chronic actinic proctitis

Tormo

Wikman-Jorgensen

Castillo

et al. 2009

Rev. esp. enferm. dig.

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show abstract

“…Risk factors Patient-related risk factors for a higher incidence of radiation-induced proctitis in general were found to be a younger age, history of previous abdominal surgery, hypertension, vasculopathy, diabetes and hemorrhoids as well as acute radiation-induced proctitis, inflammatoric bowel diseases, connective tissue diseases, and a mutation in the ataxia-teleangiectasia gene (Garg et al 2006;Gilinsky et al 1983;Lanciano et al 1992;Potish et al 1979;Tagkalidis and Tjandra 2001). Dose volume histogram (DVH) parameters Since late rectal complications are one of the main findings limiting dose escalation in prostate radiotherapy and as they are shown to be consistently correlated with DVH parameters, a big interest of radiation oncologists in that issue is obvious.…”

Section: Predictors Of Late Toxicitymentioning

confidence: 99%

Late Toxicity and Quality of Life

Geier

Geinitz

2014

Radiotherapy in Prostate Cancer

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“…Capillaries also may be the most sensitive component of the vascular system (Rodemann et al 2007a). Vascular damage is important in the phenotype of RT-induced rectal injury, where telangiectatic vessels are often responsible for the bleeding characteristic of this condition (Garg et al 2006).…”

Section: Statinsmentioning

confidence: 99%