Radiation pneumonitis after selective internal radiation treatment with intraarterial 90Yttrium-microspheres for inoperable hepatic tumors

Leung, TW; Lau, W. Y.; Ho, Stephen; Ward, SC; Chow, John; Chan, Miu Shan; Metreweli, C.; Johnson, Philip J.; Li, Arthur K.C.

doi:10.1016/0360-3016(95)00039-3

Cited by 285 publications

(187 citation statements)

References 10 publications

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“…Conditions that have been reported include gastrointestinal ulceration/bleeding, gastritis/duodenitis, cholecystitis, pancreatitis, and radiation pneumonitis [42,45,[48][49][50][51][52]. Training, careful patient selection, meticulous pretreatment assessment, and coiling of relevant vasculature reduce complication rates massively [53].…”

Section: Discussionmentioning

confidence: 99%

Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis

et al. 2008

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“…Previous preclinical and clinical studies with 90 Y microspheres have demonstrated that up to 30 Gy to the lungs could be tolerated with a single injection, and up to 50 Gy for multiple injections. 19 In cases where several treatments are administered, the lung dose is the cumulative absorbed lung radiation dose from all treatments and should not exceed 50 Gy.…”

Section: Methodsmentioning

confidence: 99%

Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis

Kulik¹,

Carr²,

Mulcahy³

et al. 2007

Hepatology

550

349

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This study was undertaken to present data from a phase 2 study in which patients with unresectable hepatocellular carcinoma (HCC) with and without portal vein thrombosis underwent radioembolization with Yttrium ( 90 Y) microspheres. Patients treated were stratified by Okuda, Child-Pugh, baseline bilirubin, tumor burden, Eastern Cooperative Oncology Group (ECOG), presence of cirrhosis and portal vein thrombosis (PVT) (none, branch, and main). Clinical and biochemical data were obtained at baseline and at 4-week intervals following treatment for up to 6 months. Tumor response was obtained using computed tomography (CT). Patients were followed for survival. One hundred eight patients were treated during the study period. Thirty-seven (34%) patients had PVT, 12 (32%) of which involved the main PV. The cumulative dose for those with and without PVT was 139.7 Gy and 131.9 Gy, respectively. The partial response rate using world Health Organization

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“…Reported side effects of Y-90 microsphere treatment are pulmonary fibrosis, gastroduodenal ulcer and radiation cholecystitis [23][24][25][26][27][28]. These adverse effects are caused by extrahepatic leakage of Y-90 microspheres.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Bremsstrahlung Images after Intra-arterial Y-90 Resin Microphere Radioembolization for Hepatic Tumors

Kim

et al. 2010

Nucl Med Mol Imaging

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Purpose Y-90 resin microsphere radioembolization is used to treat inoperable hepatic tumors. After injection of Y-90 resin microsphere, the only method to visualize the distribution of Y-90 is the scintigraphic imaging of bremsstrahlung radiation. The purpose of this study was to evaluate the characteristics and usefulness of bremsstrahlung imaging in Y-90 resin microsphere treatment. Methods Twenty patients (22 administrations) underwent intra-arterial Y-90 resin microsphere treatment. For pretreatment planning, images of Tc-99m albumin macroaggregate (MAA) arterial injection and hepatic contrast angiography were obtained. Post-treatment bremsstrahlung images were taken and compared with pre-treatment images. The extrahepatic activity was evaluated on bremsstrahlung images. To correlate the size and vascularity of the tumors with tumor visualization on bremsstrahlung images, the individual tumors were grouped according to visualization on each image and compared with one another by size and tumor-to-normal ratio. Results All post-therapeutic bremsstrahlung images showed similar contours of the liver with pre-treatment angiography. No extrahepatic activity was seen in all cases. The visualized tumors on bremsstrahlung images were significantly larger than the non-visualized tumors. Tumor-to-normal ratios of the visualized tumors on bremsstrahlung images were significantly higher than those of the non-visualized tumors. Conclusions Bremsstrahlung images after intra-arterial Y-90 resin microsphere treatment are useful in evaluating the intrahepatic distribution of radioisotope and detecting possible extrahepatic activity.

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Radiation pneumonitis after selective internal radiation treatment with intraarterial 90Yttrium-microspheres for inoperable hepatic tumors

Cited by 285 publications

References 10 publications

Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis

Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis

Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis

Usefulness of Bremsstrahlung Images after Intra-arterial Y-90 Resin Microphere Radioembolization for Hepatic Tumors

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