Radiation/Paclitaxel Treatment of p53-Abnormal Non-Small Cell Lung Cancer Xenograft Tumor and Associated Mechanism

Li, Gang; Zhao, Jingfeng; Peng, Xuebiao; Liang, Jian; Deng, Xin; Chen, Yuxiang

doi:10.1089/cbr.2011.1154

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…It is well known that the complete loss of p53 or the expressions of mutant p53 variants are commonly seen in NSCLC with 40–70% frequencies and are associated with increased resistance to chemotherapy and radiotherapy. 11 , 34 , 35 Functional p53 status may influences docetaxel and zinc-induced cytotoxicity. 11 For example, Liu et al 36 demonstrated that docetaxel induces apoptotic cell death in C4-2 and LNCaP prostate cancer cell express wild-type p53 more than DU145 (mutant p53) and PC-3 (p53-null) cells.…”

Section: Discussionmentioning

confidence: 99%

“… 11 , 34 , 35 Functional p53 status may influences docetaxel and zinc-induced cytotoxicity. 11 For example, Liu et al 36 demonstrated that docetaxel induces apoptotic cell death in C4-2 and LNCaP prostate cancer cell express wild-type p53 more than DU145 (mutant p53) and PC-3 (p53-null) cells. They also shown knockdown of p53 protein in C4-2 cells increases docetaxel resistance.…”

Section: Discussionmentioning

confidence: 99%

“… 10 By contrast, TP53 mutations are the most frequent gene abnormalities leading to inactivation of p53, which effects paclitaxel sensitivity in NSCLC. 11 …”

Section: Introductionmentioning

confidence: 99%

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Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Koçdor¹,

Ateş²,

Aydın³

et al. 2015

DDDT

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BackgroundExposure to exogenous zinc results in increased apoptosis, growth inhibition, and altered oxidative stress in cancer cells. Previous studies also suggested that zinc sensitizes some cancer cells to cytotoxic agents depending on the p53 status. Therefore, zinc supplementation may show anticancer efficacy solely and may increase docetaxel-induced cytotoxicity in non-small-cell lung cancer cells.MethodsHere, we report the effects of several concentrations of zinc combined with docetaxel on p53-wild-type (A549) and p53-null (H1299) cells. We evaluated cellular viability, apoptosis, and cell cycle progression as well as oxidative stress parameters, including superoxide dismutase, glutathione peroxidase, and malondialdehyde levels.ResultsZinc reduced the viability of A549 cells and increased the apoptotic response in both cell lines in a dose-dependent manner. Zinc also amplified the docetaxel effects and reduced its inhibitory concentration 50 (IC50) values. The superoxide dismutase levels increased in all treatment groups; however, glutathione peroxidase was slightly increased in the combination treatments. Zinc also caused malondialdehyde elevations at 50 μM and 100 μM.ConclusionZinc has anticancer efficacy against non-small-cell lung cancer cells in the presence of functionally active p53 and enhances docetaxel efficacy in both p53-wild-type and p53-deficient cancer cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Koçdor¹,

Ateş²,

Aydın³

et al. 2015

DDDT

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“…Functional p53 status may influence docetaxel and zinc-induced cytotoxicity. PTEN-PI3K-Akt-Bax signaling cascade is involved in the therapeutic effect of combined radiation/paclitaxel treatment in NSCLC without p53 expression [45].…”

Section: Zinc and Apoptosis In Lung Cancer Cells: Excess Or Default?mentioning

confidence: 99%

Zinc: What Is Its Role in Lung Cancer?

Gómez¹,

Biaggio²,

Ciminari³

et al. 2016

Nutritional Deficiency

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Recently, zinc emerged as an important signaling molecule, activating intracellular pathways and regulating cell fate, although our knowledge remains incomplete. Zinc is required in many enzymatic and metabolic pathways, playing roles as enzyme cofactors. In normal cell physiology, optimal zinc availability is essential for regular growth and proliferation. Zinc accumulation has varied effects from stimulation to inhibition of cell growth, depending on type. There is evidence that zinc is capable of inducing apoptosis in some cancers, while others proved that zinc may act as apoptosis activator depending on the dose and cell type. Upregulation of telomerase in most cancer tissues is considered to be responsible for unlimited proliferation of cancer cells, and in some cell lines, it was induced by Zn. These suggest that Zn is highly involved in cell cycle and metabolism whether it goes to the survival or the cancer pathway depends on the concentration and the cell type involved. Nevertheless, the conclusion is that Zn is not just another trace element but a vital one and further studies are needed to elucidate the mechanisms involved in cancer and metastatic spread in order to identify potential therapies.

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JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo

Wang

Zhou

Wang

et al. 2016

Cancer Chemother Pharmacol

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Radiation/Paclitaxel Treatment of p53-Abnormal Non-Small Cell Lung Cancer Xenograft Tumor and Associated Mechanism

Abstract: Our study suggested that a PTEN-PI3K-Akt-Bax signaling cascade is involved in the therapeutic effect of combined radiation/paclitaxel treatment in NSCLC without p53 expression. Our study also suggested that PTEN is an ideal target in tumors with wild-type PTEN and a lack of functional p53.

Cited by 6 publications

References 36 publications

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Zinc: What Is Its Role in Lung Cancer?

JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo

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Radiation/Paclitaxel Treatment of p53-Abnormal Non-Small Cell Lung Cancer Xenograft Tumor and Associated Mechanism

Cited by 6 publications

References 36 publications

Zinc supplementation induces apoptosis and&nbsp;enhances antitumor efficacy of docetaxel in&nbsp;non-small-cell lung cancer

Zinc supplementation induces apoptosis and&nbsp;enhances antitumor efficacy of docetaxel in&nbsp;non-small-cell lung cancer

Zinc: What Is Its Role in Lung Cancer?

JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo

Contact Info

Product

Resources

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Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer