Radiation Injury Treatment Network (RITN): Healthcare professionals preparing for a mass casualty radiological or nuclear incident

Ross, Joel; Case, Cullen; Confer, Dennis L.; Weisdorf, Daniel J.; Weinstock, David M.; Krawisz, Robert; Chute, John P.; Wilhauk, Julie; Navarro, Willis H.; Hartzman, Robert J.; Coleman, C. Norman; Hatchett, Richard; Chao, Nelson J.

doi:10.3109/09553002.2011.556176

Cited by 15 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Radiation Injury Treatment Network ® (RITN), in the U.S. fills a readiness gap in case a radiological/nuclear incident occurs that requires patient access to bone marrow transplants (157). The U.S. National Marrow Donor Program, along with the U.S. Office of Naval Research and the American Society for Blood and Marrow Transplantation collaboratively developed RITN, which is comprised of medical centers with expertise in the management of bone marrow failure, stem cell donor centers and umbilical cord blood banks across the United States.…”

Section: Discussionmentioning

confidence: 99%

Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop

et al. 2017

View full text Add to dashboard Cite

In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events. Although progress has been made by governments around the world to prepare for these events, including the stockpiling of radiation countermeasures, there are still challenges concerning care of patients injured during a radiation incident. Because the deleterious and pathological effects of radiation are so broad, it is desirable to identify medical countermeasures that can have a beneficial impact on several tissues and organ systems. Cellular therapies have the potential to impact recovery and tissue/organ regeneration for both early and late complications of radiation exposure. These therapies, which could include stem or blood progenitor cells, mesenchymal stromal cells (MSCs) or cells derived from other tissues (e.g., endothelium or placenta), have shown great promise in treating other nonradiation injuries to and diseases of the bone marrow, skin, gastrointestinal tract, brain, lung and heart. To explore the potential use of these therapies in the treatment of victims after acute radiation exposure, the National Institute of Allergy and Infectious Diseases cosponsored an international workshop in July, 2015 in Paris, France with the Institut de Radioprotection et de Sûreté Nucléaire. The workshop included discussions of data available from testing in preclinical models of radiation injury to different organs, logistics associated with the practical use of cellular therapies for a mass casualty incident, as well as international regulatory requirements for authorizing such drug products to be legally and readily used in such incidents. This report reviews the data presented, as well as key discussion points from the meeting.

show abstract

Section: Discussionmentioning

confidence: 99%

Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Radiation-related incidents would include activation of the Radiation Injury Treatment Network, a cooperative effort of the National Marrow Donor Program and the American Society for Blood and Marrow Transplantation. 76 Type II BMCI:…”

Section: Burn Mass Casualty Incident (Bmci) (Burn Disaster) Scenariosmentioning

confidence: 99%

Disaster Preparedness and Response for the Burn Mass Casualty Incident in the Twenty-first Century

Kearns

Marcozzi

Barry

et al. 2017

Clinics in Plastic Surgery

View full text Add to dashboard Cite

The effective and efficient coordination of emergent patient care at the point of injury followed by the systematic resource-based triage of casualties are the most critical factors that influence patient outcomes after mass casualty incidents (MCIs). The effectiveness and appropriateness of implemented actions are largely determined by the extent and efficacy of the planning and preparation that occur before the MCI. The goal of this work was to define the essential efforts related to planning, preparation, and execution of acute and subacute medical care for disaster burn casualties. This type of MCI is frequently referred to as a burn MCI."

show abstract

“…Research scientists including clinicians and epidemiologists are available from federal agencies as noted above in Radiation Bioterrorism Research and Training. The Radiation Injury Treatment Network (RITN) is a nongovernment group that has world renowned oncology and hematology experts and capabilities to assist in planning, treatment-protocol development, and treatment for patients with acute radiation syndrome (Ross et al 2011, NMDP 2014). …”

Section: Underlying Conceptsmentioning

confidence: 99%

“…RITN, working through the National Marrow Donor Program, established a network of over 60 U.S. academic medical centers to assist in patient management (Ross et al 2011) by providing direct care for radiation injury and guidance to other professionals (Davids et al 2010a). In an exercise, RITN demonstrated how the capacity to care for those who need management of radiation injury can be greatly enhanced by modifying the triage and medical care criteria (Davids et al 2010b).…”

Section: Response Tools and Resourcesmentioning

confidence: 99%

Public Health and Medical Preparedness for a Nuclear Detonation

Coleman¹,

Sullivan²,

Bader³

et al. 2015

Health Physics

Self Cite

View full text Add to dashboard Cite

Resilience and the ability to mitigate the consequences of a nuclear incident are enhanced by (1) effective planning, preparation and training; (2) ongoing interaction, formal exercises, and evaluation among the sectors involved; (3) effective and timely response and communication; and (4) continuous improvements based on new science, technology, experience and ideas. Public health and medical planning require a complex, multi-faceted systematic approach involving federal, state, local, tribal and territorial governments, private sector organizations, academia, industry, international partners, and individual experts and volunteers. The approach developed by the U.S. Department of Health and Human Services Nuclear Incident Medical Enterprise (NIME) is the result of efforts from government and nongovernment experts. It is a “bottom-up” systematic approach built on the available and emerging science that considers physical infrastructure damage, the spectrum of injuries, a scarce resources setting, the need for decision making in the face of a rapidly evolving situation with limited information early on, timely communication and the need for tools and just-in-time information for responders who will likely be unfamiliar with radiation medicine and uncertain and overwhelmed in the face of the large number of casualties and the presence of radioactivity. The components of NIME can be used to support planning for, response to, and recovery from the effects of a nuclear incident. Recognizing that it is a continuous work-in-progress, the current status of the public health and medical preparedness and response for a nuclear incident is provided.

show abstract

Radiation Injury Treatment Network (RITN): Healthcare professionals preparing for a mass casualty radiological or nuclear incident

Cited by 15 publications

References 17 publications

Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop

Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop

Disaster Preparedness and Response for the Burn Mass Casualty Incident in the Twenty-first Century

Public Health and Medical Preparedness for a Nuclear Detonation

Contact Info

Product

Resources

About