Radiation-induced undifferentiated pleomorphic sarcoma after radiation therapy for a desmoid tumour

Marco, Julie Di; Kaci, Rachid; Orcel, Philippe; Nizard, R.; Laredo, Jean‐Denis

doi:10.1016/j.canrad.2015.06.021

Cited by 9 publications

(10 citation statements)

References 18 publications

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“…PTS is rare thyroid cancer, with a reported incidence ranging from 0.01% to 1.5% of all thyroid malignancies [4][5][6][7]. While the exact etiology of these tumors remains unknown, some studies have reported a history of head and neck radiation in patients diagnosed with PTS [9].…”

Section: Discussionmentioning

confidence: 99%

Primary Undifferentiated Pleomorphic Thyroid Sarcoma Presenting as Superior Vena Cava Syndrome: A Case Report

Shahrokh¹,

Shahin²,

Malboosbaf³

et al. 2021

Cureus

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Primary thyroid sarcomas (PTS) are an incredibly uncommon type of thyroid cancer. Undifferentiated pleomorphic sarcomas of the thyroid (UPS-T) are extremely rare subtypes of thyroid sarcoma with no defined cell differentiation. Here, we report the case of a 60-year-old female with a two-year history of hypothyroidism who presented to our hospital with productive cough, dyspnea, and diffuse facial edema for two weeks. Her chest computed tomography (CT) scan revealed a large anterior mediastinal mass and multiple bilateral pulmonary nodules. Her thyroid ultrasound showed two hypoechoic nodules, while a CTvenogram of the right upper extremity showed superior vena cava and the right brachiocephalic vein obstruction, which was relieved with angioplasty. A biopsy of the anterior mediastinal mass showed poorly differentiated pleomorphic thyroid sarcoma. The patient was not a candidate for inpatient chemo-or radiotherapy because of her overall medical condition. One week later, she developed worsening respiratory failure, was intubated and transferred to the intensive care unit (ICU), where she passed away two days later.

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Section: Discussionmentioning

confidence: 99%

Primary Undifferentiated Pleomorphic Thyroid Sarcoma Presenting as Superior Vena Cava Syndrome: A Case Report

Shahrokh¹,

Shahin²,

Malboosbaf³

et al. 2021

Cureus

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“…Functional complications after radiotherapy are well known, due to the in general unimpaired life expectancy in DF also radiation-induced malignancies should be considered. [ 36 ]…”

Section: Discussionmentioning

confidence: 99%

Desmoid Tumours of the extremity and trunk. A retrospective study of 44 patients

Wirth¹,

Klein²,

Baur‐Melnyk³

et al. 2018

BMC Musculoskelet Disord

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BackgroundDesmoid-type fibromatosis (DF) is a aggressive (myo)fibroblastic neoplasm with an infiltrative growth and a tendency to local recurrence. Resection of the tumour and/or radiation were proposed as principal treatment. The aim of this retrospective study was to analyze the local control rates focusing on the effect of surgical margins and radiotherapy.MethodsFrom 1981 to 2014, 44 patients had been treated. Fifty four therapies had been applied, in 50 cases surgery +/− radiation therapy, NSAIDs or chemotherapy. In 4 cases a conservative approach was chosen. Thirty seven patients had primary, 17 recurrent disease. Endpoint was either local recurrence (LR), progression of residual disease or rare non-metastatic secondary lesions at the same extremity.ResultsThe mean age was 39,4 years. In 17 cases a R0, in 27 a R1 and in 6 cases a R2 resection was achieved. Four patients were treated conservatively. All together in 21 cases radiotherapy, in 5 NSAIDs, in 3 imatinib and in 2 cases each tamoxifen or chemotherapy had been applied. The median follow-up was 119 months. 5-year recurrence free survival after resection was 78%. 10 (20.4%) patients developed LR between 5 and 42 months after therapy. Recurrent disease was a negative factor on LR. Margins, radiotherapy, sex, or size of the tumour had no significant impact on LR. Patients younger than 40 years had a significant higher risk of LR.ConclusionsSurgical margins are less important than keeping function. Radiotherapy might be an option in unresectable lesions, the role of adjuvant radiotherapy is controversially discussed.

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“…The cause of UPS-T has not been identified in most patients in the literature, but some patients developed UPS-T after radiotherapy. [ 18 ] However, there was no history of radiotherapy in our patient. Although there is no consensus within the literature on a comprehensive treatment plan for patients with undifferentiated pleomorphic sarcoma, surgery plays a central role in nearly all cases.…”

Section: Discussionmentioning

confidence: 85%

Primary undifferentiated pleomorphic sarcoma of the thyroid

Chen

Huang²,

Yan³

et al. 2018

Medicine

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Rationale:Primary undifferentiated pleomorphic sarcoma is extremely rare in the thyroid, and can be easily misdiagnosed as anaplastic thyroid cancer.Patient concerns:We present a case of a 71-year-old woman who presented with a rapidly growing painless mass in the neck.Diagnoses–interventions–outcomes:Computed tomography showed a large hypointense mass with hyperdense areas involving whole of the right lobe of thyroid gland and fine-needle aspiration cytology found a few atypical cells. Surgical exploration was performed subsequently and frozen section showed malignant tumor. Therefore, a total thyroidectomy, central, and bilateral lateral neck dissection were performed and adjuvant radiotherapy of 60 Gy was administered. The patient was alive and had no recurrence at 6-month follow-up.Lessons:Although primary undifferentiated pleomorphic sarcoma in the thyroid is extremely rare, patients who presented with a rapidly growing painless mass in the neck should be considered and it is essential to excise the tumor completely as soon as possible.

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Radiation-induced undifferentiated pleomorphic sarcoma after radiation therapy for a desmoid tumour

Cited by 9 publications

References 18 publications

Primary Undifferentiated Pleomorphic Thyroid Sarcoma Presenting as Superior Vena Cava Syndrome: A Case Report

Primary Undifferentiated Pleomorphic Thyroid Sarcoma Presenting as Superior Vena Cava Syndrome: A Case Report

Desmoid Tumours of the extremity and trunk. A retrospective study of 44 patients

Primary undifferentiated pleomorphic sarcoma of the thyroid

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