Radiation-induced Tumorigenesis

Kim, In-Gyu; Lee, Yun-Sil Lee

doi:10.5483/bmbrep.2003.36.1.144

Cited by 5 publications

(2 citation statements)

References 7 publications

(7 reference statements)

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“…Although chromosomal translocations can lead to oncogene activation, the main radiation-induced carcinogenic processes seem to involve a wide variety of stable chromosomal aberrations, including deletions and reciprocal translocations, rather than the point mutations predominating in spontaneous mutations. Gene and/or chromosomal rearrangements and loss of heterozygosity are thus considered the most likely radiation-induced events that contribute to cancer development [18].…”

Section: Molecular Mechanisms Of Carcinogenesis Induced By Ionizing Rmentioning

confidence: 99%

Is radioiodine treatment for thyroid cancer a risk factor for second primary malignancies?

Dottorini

Salvatori

2013

Clin Transl Imaging

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Radioiodine is a safe and well-established therapeutic modality for the ablation of thyroid remnants and the treatment of locoregional and distant metastases from differentiated thyroid carcinoma. However, a careful hazard assessment is mandatory in order to establish the risk-benefit ratio, especially in low-risk patients. Induction of second primary malignancies is one of the most serious possible untoward effects of radioiodine treatment. The limited incidence both of this effect and of thyroid cancer and the paucity of available dosimetric data make it difficult to perform high-quality studies that could provide evidence-based indications. A number of bias and confounding factors can blur data and must be considered, evaluating studies, addressing this topic. Data from the main surveys confirm that radioiodine can induce second primary tumors, with a probability comparable to that of external radiotherapy and lower than that of chemotherapy. Even though radioiodine treatment of thyroid cancer carries a low relative risk, the process of therapy justification must be carefully conducted and every measure that can reduce patient exposure must be taken, especially in children, adolescents and young adults.

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Section: Molecular Mechanisms Of Carcinogenesis Induced By Ionizing Rmentioning

confidence: 99%

Is radioiodine treatment for thyroid cancer a risk factor for second primary malignancies?

Dottorini

Salvatori

2013

Clin Transl Imaging

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“…R adiation in physics, various chemical carcinogens and biological factors could cause tumorigenesis [1][2][3] . 9.6 million people around the world were estimated to have died from cancers in 2018 according to WHO and 1 out of 6 deaths is due to cancer, globally.…”

Section: Introductionmentioning

confidence: 99%

Research progress of anti-tumor active ingredients in Dandelion

Xie¹,

Huang

Wang

2020

Jour. of oncol. res.

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As a traditional Chinese herb, dandelion, containing complicated active ingredients which includes polysaccharide, flavonoid, terpene, pigment, phytosterol, coumarin, organic acid and etc, plays significant roles in various physiological activities in organisms. The active ingredients generally interfere in signal transduction of cancer cells, regulate cell cycle and apoptotic protein expression, inhibits proliferation and migration of cancer cells and etc, to effectively restrain tumor development and deterioration. This article summarizes the anti-tumor mechanism of five active ingredients in dandelion through paper reading which provides thoughts and references for anti-tumor research.

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Second solid cancers after allogeneic hematopoietic stem cell transplantation

Gallagher

Forrest

2006

Cancer

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The specific roles of classical cadherins at key morphogenetic events during development are still not fully understood. As part of a project to study cadherin function during early mammalian development, we generated mice carrying an HA‐epitope tagged Cdh1 (E‐cadherin) cDNA knocked into the Cdh1 locus, similar to the previously described mouse mutants in which we forced Cdh2 (N‐cadherin) expression in the Cdh1 expression domain. As expected and in contrast to Cdh1Cdh2/Cdh2 and Cdh1−/−, our Cdh1HA/HA mutant embryos form proper trophectoderm, implant and undergo both gastrulation and neurulation. However, Cdh1HA/HA mice display an unexpected phenotype at embryonic day 10.5. Cdh1HA/HA embryos are smaller, paler and suffer from an insufficient nutrient supply. We detected a reduced expression of Cdh1HA specifically in the extraembryonic ectoderm and in the labyrinth layer, whereas expression in the embryo proper was normal. With this approach, we show for the first time that Cdh1 is essential for the correct formation of the placenta. Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport. Developmental Dynamics 239:2330–2344, 2010. © 2010 Wiley‐Liss, Inc.

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Radiation-induced Tumorigenesis

Cited by 5 publications

References 7 publications

Is radioiodine treatment for thyroid cancer a risk factor for second primary malignancies?

Is radioiodine treatment for thyroid cancer a risk factor for second primary malignancies?

Research progress of anti-tumor active ingredients in Dandelion

Second solid cancers after allogeneic hematopoietic stem cell transplantation

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