Radiation-Induced Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia

Alkan, Ali; Kütük, Tuğçe; Karcı, Ebru; Yaşar, Arzu; Hiçsönmez, A; Utkan, Güngör

doi:10.4274/tjh.2015.0259

Cited by 10 publications

(6 citation statements)

References 9 publications

(10 reference statements)

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“…However, corticosteroids, radiation, hormonal agents, or antibodies may also cause a significant TLS. 22 – 24 Less frequent, spontaneous TLS can develop prior to initiation of anticancer therapy. 11 , 13 , 25 , 26 Even invasive procedure like biopsies, 16 embolization, 27 , 28 and tumor surgery 29 could lead to TLS.…”

Section: Incidencementioning

confidence: 99%

Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase

Alakel¹,

Middeke²,

Schetelig³

et al. 2017

OTT

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Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized by acute renal failure, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. While limited options are available for treating TLS, identifying patients at high risk for developing TLS and prevention in high-risk patients remain an important aspect in the treatment of cancer patients. In general, treatment of TLS consists of intensive hydration, stimulation of diuresis, and, more specifically, in the use of allopurinol and rasburicase. Rasburicase, a recombinant urate oxidase, rapidly and effectively reduces hyperuricemia, which subsequently significantly decreases the risk of acute renal failure and other clinical manifestations of TLS. For this review, a comprehensive literature search using the term “tumor lysis syndrome” and/or “rasburicase” was performed considering articles listed in MEDLINE. Incidence, prevention, and therapy of TLS with a special focus on the role of rasburicase are discussed. We evaluated 120 relevant articles including 35 case reports, 32 clinical trials, and 14 meta-analyses.

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Section: Incidencementioning

confidence: 99%

Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase

Alakel¹,

Middeke²,

Schetelig³

et al. 2017

OTT

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“…In addition, previous studies have also focused on the effects of the exposure to non-ionizing radiofrequencies on brain tumors, leukemia, salivary gland tumors, infertility and electro-hypersensitivity ( 3 , 6 , 19 , 20 ). Although a number of studies have investigated the association between exposure to radiation and cancer, the majority of meta-analysis studies have focused on the association between mobile phones and tumors ( 21-23 ) or electromagnetic fields and breast cancer ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

Exposure to radiofrequency radiation increases the risk of breast cancer: A systematic review and meta‑analysis

et al. 2020

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The present systematic review and meta-analysis investigated the association between exposure to radiofrequency radiation and the risk of breast cancer. The published studies that were available in PubMed, Embase, Cochrane Library, Ovid MEDLINE, CINAHL Plus, Web of Science, Airiti Library, Networked Digital Library of Theses and Dissertations and ProQuest until May 2020 were investigated. A total of eight studies (four case-control and four cohort studies) were eligible for quantitative analysis. A significant association between radiofrequency radiation exposure and breast cancer risk was detected [pooled relative risk (RR)=1.189; 95% confidence interval (CI), 1.056-1.339]. Subgroup analyses indicated that radiofrequency radiation exposure significantly increased the risk of breast cancer susceptibility among subjects aged ≥50 years (RR=2.179; 95% CI, 1.260-3.770). Pooled estimates revealed that the use of electrical appliances, which emit radiofrequency radiation, such as mobile phones and computers, significantly increased breast cancer development (RR=2.057; 95% CI, 1.272-3.327), while occupational radiofrequency exposure and transmitters did not increase breast cancer development (RR=1.274; 95% CI, 0.956-1.697; RR=1.133; 95% CI, 0.987-1.300, respectively). It was concluded that radiofrequency radiation exposure significantly increased the risk of breast cancer, especially in women aged ≥50 years and in individuals who used electric appliances, such as mobile phones and computers. In accordance with Preferred Reporting Items for Systematic Reviews and Meta-analysis, an evaluation protocol was prepared and registered with the PROSPERO database (registration no. CRD42018087283).

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“…Table II shows the available reports on RT-induced TLS (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Two studies reported three cases of RT-induced TLS in MM (19,20).…”

Section: Discussionmentioning

confidence: 99%

Palliative Radiotherapy Induced Severe Tumor Lysis Syndrome in a Patient With Multiple Myeloma With Skin Involvement: A Case Report and Review of Literature

Kawamoto

Karino

Muramoto

et al. 2023

CDP

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Background/Aim: Radiotherapy (RT) has been rarely reported as a cause of tumor lysis syndrome (TLS). Therefore, the patient characteristics and details of RT-induced TLS remain unclear, which may delay diagnosis. Herein, we report a case of palliative RT-induced severe TLS in a patient with multiple myeloma (MM) with skin involvement along with literature review. Case Report: A 75-year-old female with MM was referred to our department in February 2021 because of swelling and pruritus of the bulky tumor on her right breast and severe left leg pain. She had received chemotherapies and autologous peripheral blood stem cell transplantations since October 2012. We administered palliative RT (a single 8 Gy fraction) to the right breast, left tibia, and femur. On day 7 after RT, a shrinkage effect was observed on the right breast lesion, and left leg pain was relieved. Her laboratory results showed hyperuricemia, hyperphosphatemia, and hypercreatininemia. Initially, we considered acute renal failure (ARF) due to MM progression and planned for a follow-up after 1 week. On day 14 after RT completion, she experienced vomiting and anorexia. Her laboratory results became worse. She was admitted with the diagnosis of TLS and received intravenous fluid hydration and allopurinol. Unfortunately, the evolution was marked by severe clinical deterioration with anuria and coma, leading to death on day 35 after RT. Conclusion: It is important to determine whether ARF is due to MM progression or TLS. The occurrence of TLS should be considered in the case of a rapidly shrinking bulky tumor while receiving palliative RT.

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Radiation-Induced Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia

Cited by 10 publications

References 9 publications

Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase

Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase

Exposure to radiofrequency radiation increases the risk of breast cancer: A systematic review and meta‑analysis

Palliative Radiotherapy Induced Severe Tumor Lysis Syndrome in a Patient With Multiple Myeloma With Skin Involvement: A Case Report and Review of Literature

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