Radiation Induced Transformation in Primary Differentiated Thyroid Cultures

Seymour, Colin; Mothersill, Carmel

doi:10.1007/978-1-4684-5269-3_12

Cited by 1 publication

(1 citation statement)

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“…It was subsequently shown that the system could be used to culture human thyroid and that similar transformed characteristics could be found several passages distant from the point of irradiation [70, 711. The system has also been used to look at the response of human and sheep thyroid cells to 1311 irradiation over a long period and has potential for giving useful dose-response data in this area [77]. The level of differentiation obtainable is high, follicular development, T, production and iodine trapping being detectable [ 70, 721.…”

Section: Development Of New Transformation Systemsmentioning

confidence: 99%

Radiation transformation studies: are they relevant to radiation protection problems?

Seymour

Mothersill

1988

J. Radiol. Prot.

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Radiation induced cancer is of considerable interest in the field of radiation protection. Because of the difficulties of studying carcinogenesis in humans, several in vitro systems are utilised. These cell transformation systems are reviewed, with particular emphasis on their relevance to human radiological protection problems. Most available systems use rodent fibroblasts. These are discussed in detail, since considerable amounts of radiation transformation dose response data have been derived from them. Attention is drawn to certain artefacts which can cause problems with interpretation of such data. The relevance of these systems is questionable because of species differences, particularly concerning life span and because most human tumours are derived from epithelial cells. New epithelial culture systems and three-dimensional tissue culture methods becoming available are discussed in the light of their potential for addressing radiation protection problems.

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Section: Development Of New Transformation Systemsmentioning

confidence: 99%