Radiation-induced synthesis of thermo-sensitive, gradient hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate

The influence of selected NSAIDs on volume phase transition in poly(2-(2-methoxyethoxy)ethyl methacrylate) hydrogels

“…Simultaneous polymerisation and cross-linking of PMEO 2 MA was attained via electron-beam irradiation of a mixture of 2-(2methoxyethoxy)ethyl methacrylate (MEO 2 MA), 2-hydroxyethylmethacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) (molar ratios: 100 : 2 : 1). 16 Such composition of substrates and an irradiation dose of 30 kGy were selected to obtain a firm gel with good mechanical properties and, simultaneously, with a high degree of swelling (DS). The irradiation process was carried out at room temperature in 2 ml glass ampoules using the linear accelerator ELU-6 (Eksma, Russia) with a dose rate of ca.…”

“…After irradiation, gels were conditioned for 24 hours at 50 1C to avoid phase separation being a post-polymerisation effect in the utilized system, as we observed previously. 16 After synthesis, the gels were immersed and equilibrated in deionized water (Merck Millipore Water Purification System) at 7 1C to extract both sol fraction and unreacted substrates. Water was exchanged every two days until the equilibrium degree of swelling has been reached.…”

“…Hydrogels based on thermo-responsive polymers belonging to the poly(oligo(ethylene glycol)methacrylate) (POEGMA) group, such as PMEO 2 MA, are distinguishable by the tuneable, fully reversible and sharp VPT with small hysteresis. 13 A multitude of synthesis methods useful for their preparation (free radical polymerisation -FRP, 15 radiation-induced free radical polymerisation -RI-FRP, 16 atom transfer radical polymerisation -ATRP, 17 reversible addition-fragmentation chain transfer -RAFT 18 ) and a variety of feasible structures (bare and decorated networks, brushes, 19 stars, 20 nano-, micro-and macrogels 21 ) are also important advantages of POEGMA materials.…”

Raman spectroscopy study on influence of network architecture on hydration of poly(2‐(2‐methoxyethoxy)ethyl methacrylate) hydrogels

“…Poly(2‐(2‐methoxyethoxy)ethyl methacrylate) (PMEO 2 MA) has recently gained a great attention as a biocompatible and bioinert polymer. Various polymerization methods allowed designing PMEO 2 MA hydrogels with precisely tailored structure . In the present study, an influence of PMEO 2 MA network architecture on its hydration is discussed and compared with the thermal behaviors of the gels.…”

“…In the present study, an influence of PMEO 2 MA network architecture on its hydration is discussed and compared with the thermal behaviors of the gels. Specifically, the material with random network obtained via radiation‐induced free radical polymerization and cross‐linking (FRPC) is compared with a more regular structure formed by atom transfer radical polymerization (ATRP) . Two types of regular networks were investigated: bare one and decorated with dangling chains.…”