Radiation-Induced Strand Breakage in DNA

Jf, Ward

doi:10.1007/978-1-4684-2898-8_7

Cited by 5 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complex lesions, such as clustered DSBs and LMDS (locally multiply damaged sites) may also occur. After these complex lesions, DSBs are the most harmful lesions to the cell (Ward, 1975). It has been shown, in rodent cells, that the extent of cell death is directly correlated with the yield of DSB under various X-ray irradiation conditions (Radford, 1985).…”

Section: Dynamics and Heterogeneity Of Dna Damagementioning

confidence: 99%

SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses

Quanz¹,

Croset²,

Dutreix³

2011

Selected Topics in DNA Repair

View full text Add to dashboard Cite

Section: Dynamics and Heterogeneity Of Dna Damagementioning

confidence: 99%

SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses

Quanz¹,

Croset²,

Dutreix³

2011

Selected Topics in DNA Repair

View full text Add to dashboard Cite

“…Many types of damage may contribute to cell death, however, much of the available information to date is concerned with single and double strand breaks in the DNA, their yield, rejoining and biological significance (Johansen 1975). Studies of in uitro model systems (Ward 1975) and in uiuo cell DNA (Johansen 1975) reveal a multitude of mechanisms of possible DNA strand breakage resulting in different DNA strand termini. Depending on the nature of the DNA strand breaks different repair mechanisms must be employed by the cell.…”

Section: Dna Lesionsmentioning

confidence: 99%

Bacterial Spores: Biophysical Aspects of Recovery From Radiation Injury

Grecz

Wiatr

Durban

et al. 1978

J Food Processing Preservation

View full text Add to dashboard Cite

Differences in radiation resistance of 14 strains of Clostridium botulinum spores could be correlated by computer analysis with differences in the lug or shoulder portion (L) of their respective radiation sur vival curves. The exponential decline portions (E) of the survival curves were nearly identical for all 14 strains. Autoradiographic, and diphenylamine assays indicated that strains 33A, 62A and 51B contained 1, 2 and 2 genomes per spore, respectively. However, no relationship could be detected between number of genomes and radiation resistance of the spores. Alkaline sucrose gradient sedimentation of sH-DNA indicated that L was characterized by production of D N A single-strand breaks (SSB). Radiation resistant strain 33A rejoined 50-90% of the initial SSB during irradiation or shortly thereafter, i.e. while the spores were still in the cryptobiotic dormant state. Rejoining of SSB seems to be due to high DNA-ligase activity in strain 33A. On the other hand, the radiation sensitive strain 51B showed no shoulder (L) and very little or no SSB rejoining. The exponential decline portion (E) seems to be associated with those lesions which cannot be repaired during irradiation or germination. I t is thought that repair of these lesions is attempted after germination and initiation of metabolism and may involve DNA excision-resynthesis, and recombination. These repair mechanisms are errorprone and thus f r e quently result in cell death characteristic of the E portion o f the survival curve. Journal o f Food Processing and Preservation 2 (1978) 315-337. All Rights Reserved @Copyright 1979 by Food

show abstract

Molecular radiobiology and the origins of the base excision repair pathway: an historical perspective

Wallace

2021

International Journal of Radiation Biology

View full text Add to dashboard Cite

Radiation-Induced Strand Breakage in DNA

Cited by 5 publications

References 3 publications

SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses

SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses

Bacterial Spores: Biophysical Aspects of Recovery From Radiation Injury

Molecular radiobiology and the origins of the base excision repair pathway: an historical perspective

Contact Info

Product

Resources

About