Radiation‐induced skin fibrosis after treatment of breast cancer: profilometric analysis

Abstract

This study shows a breakdown effect of irradiation on the skin in correlation with the fibrosis inducing by ionising radiation. The imprints modifications are clearly different from those usually observed in the ageing process. Our results can be a basis for studying the effects of treatments on cutaneous complications linked to the radiation-induced fibrosis.

A randomized, prospective study using the LPG® technique in treating radiation‐induced skin fibrosis: clinical and profilometric analysis

“…On the 3D images, it could be seen that the wrinkles were all aligned in a specific direction compared with the non-irradiated control breasts. Together, all these observations support the fact that radiation treatment has a restructuring effect on the skin micro-contours, related to the radiation-induced fibrosis (10).…”

ShRNA‐mediated matrix metalloproteinase‐2 gene silencing protects normal cells and sensitizes cancer cells against ionizing‐radiation induced damage

“…IR affects the skin and subcutaneous tissue and short term exposure to IR causes skin erythema and alopecia, whereas long term exposure causes fibrosis, ischemia, atrophy, and malignant transformation . IR triggers severe systemic effects apart from causing cataracts, leukemia, and other cancers …”

Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography

“…Large treatment fields are more likely to damage critical mass of epidermal stem cells leading to long-term progressive hardening, edema, modifying microrelief of the skin surface, and causing the changes in dermal thickness. 12 Radiation also damages the vasculature of the dermis, progressively changing superficial blood vessel structure (Fig. 1), and often leading to telangiectasia-a prominent, dilated (enlarged), and tortuous microvasculature near the skin surface.…”