Radiation-induced pemphigus vulgaris of the breast

Vigna‐Taglianti, Riccardo; Russi, Elvio; Denaro, Nerina; Numico, Gianmauro; Brizio, Rodolfo

doi:10.1016/j.canrad.2011.01.006

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…In particular, atopic eczema, which very frequently affects the head and neck area, is associated with skin that is very sensitive to a variety of environmental factors including heat, solar radiation, detergents, and water. In addition, ionizing radiation may elicit or exacerbate autoimmune bullous disease such as pemphigus [33][34][35]. 2.…”

Section: Host Factorsmentioning

confidence: 99%

Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

Russi

Moretto

Rampino

et al. 2015

Critical Reviews in Oncology/Hematology

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The adverse effects of radiation therapy, often integrated with chemotherapy and/or targeted therapies, on the skin include severe acute and chronic dermatitis associated with pain, discomfort, itching, and burning, and may heavily affect patients' quality of life. The management of these skin adverse effects in head and neck cancer patients (HNCPs) are very heterogeneous due to the lack of shared rigorous classification systems and evidence based treatments. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of dermatitis in HNCPs treated with radiotherapy with or without systemic therapies in order to improve skin toxicity management. The Delphi Appropriateness Method was used. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. This paper offers contains seven clusters of statements about the management of dermatitis in HNCPs and a review of recent literature on these topics.

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Section: Host Factorsmentioning

confidence: 99%

Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

Russi

Moretto

Rampino

et al. 2015

Critical Reviews in Oncology/Hematology

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“…There are several reports of radiotherapy-induced pemphigus vulgaris, but not of the vegetans variant. Reported cases are restricted to the irradiated area, 2 , 3 (similarly to the case described here) or generalized. 4 , 5 There have also been reports of pemphigus foliaceus induction.…”

Section: What Is Your Diagnosis?mentioning

confidence: 99%

Case for diagnosis. Radiotherapy-induced pemphigus vegetans

Almeida

Martinez

et al. 2022

Anais Brasileiros de Dermatologia

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“…The mechanisms responsible for RT induced pemphigus share some similarities to that of DIP. Specifically, ionizing radiation is said to increase the antigenicity of keratinocytic surface molecules via peptidyl sulfhydryl disruptive mechanisms ( 42 , 48 , 49 , 59 ). There are only two reported cases of DIP developed in a patient after treatment with the immunotherapeutic agent nivolumab ( 46 , 47 ).…”

Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, that confer disease risk. Although HLA is required, it is not sufficient for the initiation of disease. As with all autoimmune diseases, the etio-pathogenesis of PV is complex, meaning it is multifactorial. Susceptibility is polygenic, and the search for non-HLA disease-linked genes continues. Moreover, twin studies across autoimmune conditions indicate that non-genetic environmental and lifestyle factors, which can be collectively grouped under the term “exposome”, are also major contributors to disease development. The literature presents evidence for the potential role of multiple triggers such as medications, infections, stress, diet, immunizations, and sleep to influence the etiology, pathophysiology, and prognosis of PV. However, a clear understanding of the degree to which specific factors impact PV is lacking. In this investigation, we comprehensively review the environmental elements listed above and consider the strength of evidence for these factors. The overall goals of this work are to provide greater insights into the factors that influence disease susceptibility, disease development and disease course and ultimately help to better guide clinicians and inform patients in the management of PV.

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Radiation-induced pemphigus vulgaris of the breast

Cited by 11 publications

References 19 publications

Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

Case for diagnosis. Radiotherapy-induced pemphigus vegetans

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

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