Radiation-induced osteochondromas.

Libshitz, HI; Cohen, Michael A.

doi:10.1148/radiology.142.3.6278535

Cited by 86 publications

(48 citation statements)

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“…Radiation-induced osteochondromas occur at an incidence of 10% to 12% after radiotherapy and an incidence of 10% to 24% after TBI. [44][45][46][47] Younger children are at greatest risk because of their greater growth potential. Chemotherapy and radiotherapy can arrest growth and cause epiphyses to remain open longer than usual, permitting osteochondromas to develop.…”

Section: Discussionmentioning

confidence: 99%

Final adult height of patients who received hematopoietic cell transplantation in childhood

Sanders

Guthrie

Hoffmeister

et al. 2005

Blood

104

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Growth impairment and growth hormone (GH) deficiency are complications after total body irradiation (TBI) and hematopoietic cell transplantation (HCT). To determine the impact of GH therapy on growth, the final heights of 90 GH-deficient children who underwent fractionated TBI and HCT for malignancy were evaluated. Changes in height standard deviation (SD) from the diagnosis of GH deficiency to the achievement of final height were compared among 42 who did and 48 who did not receive GH therapy. At HCT, GHtreated patients were younger (P ‫؍‬ .001), more likely to have undergone central nervous system irradiation (P ‫؍‬ .007), and shorter (P ‫؍‬ .005) than patients who did not receive GH therapy. After HCT, GH deficiency was diagnosed at 1.5 years (range, 0.8-9.5 years) for GH-treated and 1.2 years (range, 0.9-8.8 years) for nontreated patients. GH therapy was associated with significantly improved final height in children younger than 10 years at HCT (P ‫؍‬ .0001), but GH therapy did not impact the growth of older children.

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Section: Discussionmentioning

confidence: 99%

Final adult height of patients who received hematopoietic cell transplantation in childhood

Sanders

Guthrie

Hoffmeister

et al. 2005

Blood

104

View full text Add to dashboard Cite

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“…The prevalence of (benign) osteochondroma after RT in patients with unfused physes has been reported to be 12% at 8 years-a prevalence incidence higher than in Anteroposterior radiographs show a classic osteosarcoma in the distal femur; the exact proximal extent of the tumor is unclear. c Coronal T1-weighted SE MR image readily shows the proximal extent of abnormal marrow (arrow), which extends into the proximal diaphysis spontaneous osteochondroma (1%) [31]. An RT-induced sarcoma of bone is rather rare, constituting less than 1.5% of all bone sarcomas [32].…”

Section: Post-treatment Changesmentioning

confidence: 99%

Magnetic resonance imaging of bone marrow in oncology, Part 2

Hwang

Panicek

2007

Skeletal Radiol

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Magnetic resonance imaging plays an integral role in the detection and characterization of marrow lesions, planning for biopsy or surgery, and post-treatment followup. To evaluate findings in bone marrow on MR imaging, it is essential to understand the normal composition and distribution of bone marrow and the changes in marrow that occur with age, as well as the basis for the MR signals from marrow and the factors that affect those signals; these points have been reviewed and illustrated in part 1 of this two-part article. Part 2 will emphasize the practical application of MR imaging to facilitate differentiation of normal marrow, tumor, and treatment-related marrow changes in oncology patients, and will review complementary MR techniques under development.

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“…Second, ovarian dysfunction and adverse pregnancy outcomes (spontaneous abortions and small-fordates infants) have been reported [7,[9][10][11][12][13] in female survivors. Finally, second primary tumors [5], both benign (e.g., osteochondroma) [14] and malignant (e.g., soft tissue sarcoma, osteosarcoma, and adenocarcinoma of the colon and liver) [15][16][17], may be radiation-associated. In addition, there is the theoretical risk that the abdominal radiotherapy field may involve the heart and thereby potentiate the effects of doxorubicin [4].…”

Section: Introductionmentioning

confidence: 99%